User profiles for Henry J. Sutton
Henry J SuttonInstructor at La Jolla Institute For Immunology Verified email at lji.org Cited by 573 |
[HTML][HTML] Long-primed germinal centres with enduring affinity maturation and clonal migration
Germinal centres are the engines of antibody evolution. Here, using human immunodeficiency
virus (HIV) Env protein immunogen priming in rhesus monkeys followed by a long period …
virus (HIV) Env protein immunogen priming in rhesus monkeys followed by a long period …
[PDF][PDF] Atypical B cells are part of an alternative lineage of B cells that participates in responses to vaccination and infection in humans
The diversity of circulating human B cells is unknown. We use single-cell RNA sequencing (RNA-seq)
to examine the diversity of both antigen-specific and total B cells in healthy …
to examine the diversity of both antigen-specific and total B cells in healthy …
[PDF][PDF] Antibody feedback limits the expansion of B cell responses to malaria vaccination but drives diversification of the humoral response
Generating sufficient antibody to block infection is a key challenge for vaccines against
malaria. Here, we show that antibody titers to a key target, the repeat region of the Plasmodium …
malaria. Here, we show that antibody titers to a key target, the repeat region of the Plasmodium …
[HTML][HTML] T-dependent B cell responses to Plasmodium induce antibodies that form a high-avidity multivalent complex with the circumsporozoite protein
CR Fisher, HJ Sutton, JA Kaczmarski… - PLoS …, 2017 - journals.plos.org
The repeat region of the Plasmodium falciparum circumsporozoite protein (CSP) is a major
vaccine antigen because it can be targeted by parasite neutralizing antibodies; however, little …
vaccine antigen because it can be targeted by parasite neutralizing antibodies; however, little …
[PDF][PDF] Avid binding by B cells to the Plasmodium circumsporozoite protein repeat suppresses responses to protective subdominant epitopes
Antibodies targeting the NANP/NVDP repeat domain of the Plasmodium falciparum
circumsporozoite protein (CSP Repeat ) can protect against malaria. However, it has also been …
circumsporozoite protein (CSP Repeat ) can protect against malaria. However, it has also been …
Malaria exposure drives both cognate and bystander human B cells to adopt an atypical phenotype
R Aye, HJ Sutton, EW Nduati, O Kai… - European journal of …, 2020 - Wiley Online Library
Atypical memory B cells (aMBCs) are found in elevated numbers in individuals exposed to
malaria. A key question is whether malaria induces aMBCs as a result of exposure to Ag, or …
malaria. A key question is whether malaria induces aMBCs as a result of exposure to Ag, or …
Lack of affinity signature for germinal center cells that have initiated plasma cell differentiation
Long-lived plasma cells (PCs) secrete antibodies that can provide sustained immunity against
infection. High-affinity cells are proposed to preferentially select into this compartment, …
infection. High-affinity cells are proposed to preferentially select into this compartment, …
Dysregulation of PAX5 causes uncommitted B cell development and tumorigenesis in mice
…, TD Andrews, X Li, V Cho, AC Mosquera, HJ Sutton… - bioRxiv, 2021 - biorxiv.org
PAX5 is the master transcription factor controlling B cell identity. In humans, mutations in
PAX5 account for 30% of B cell acute lymphoblastic leukemia (B-ALL) cases. Investigating the …
PAX5 account for 30% of B cell acute lymphoblastic leukemia (B-ALL) cases. Investigating the …
A point mutation in IKAROS ZF1 causes a B cell deficiency in mice
…, Y Sontani, Y Mei, D Howard, HJ Sutton… - The Journal of …, 2021 - journals.aai.org
IKZF1 (IKAROS) is essential for normal lymphopoiesis in both humans and mice. Previous
Ikzf1 mouse models have demonstrated the dual role for IKZF1 in both B and T cell …
Ikzf1 mouse models have demonstrated the dual role for IKZF1 in both B and T cell …
[PDF][PDF] Thomas Sutton and Henry of Ghent on the analogy of being
G Klima - Proceedings of the Society for Medieval Logic and …, 2002 - Citeseer
… In the particular case of Henry‘s and Sutton‘s disagreement, the most striking difference I …
and existence in creatures, Sutton uses what he takes to be the absurd implication of Henry‘s …
and existence in creatures, Sutton uses what he takes to be the absurd implication of Henry‘s …