For more than 100 years, the fruit fly Drosophila melanogaster has been one of the most
studied model organisms. Here, we present a single-cell atlas of the adult fly, Tabula …

Although subcellular mRNA trafficking has been demonstrated as a mechanism to control
protein distribution, it is generally believed that most protein localization occurs subsequent to …

Nuclear receptors are a family of transcription factors with structurally conserved ligand
binding domains that regulate their activity. Despite intensive efforts to identify ligands, most …

The past decade has seen a major increase in the study of noncoding RNAs (ncRNAs).
However, there remains a great deal of confusion and debate over the levels of functionality and …

The zebrafish (Danio rerio) is an emerging vertebrate model for drug discovery that permits
whole animal drug screens with excellent throughput, combined with ease of use and low …

Our recent ability to sequence entire genomes, along with all of their transcribed RNAs, has
led to the surprising finding that only ∼1% of the human genome is used to encode proteins. …

Scalloped (Sd) and Vestigial (Vg) are each needed forDrosophila wing development. We
show that Sd is required for Vg function and that altering their relative cellular levels inhibits …

In a previous analysis of 2300 mRNAs via whole-mount fluorescent in situ hybridization in
cellularizing Drosophila embryos, we found that 70% of the transcripts exhibited some form of …

Nuclear hormone receptors and homeodomain proteins are two classes of transcription
factor that regulate major developmental processes. Both depend on interactions with other …

Heme is a ligand for the human nuclear receptors (NR) REV-ERBα and REV-ERBβ, which
are transcriptional repressors that play important roles in circadian rhythm, lipid and glucose …