[HTML][HTML] Endogenous formaldehyde scavenges cellular glutathione resulting in redox disruption and cytotoxicity

…, O Pak, K Kolesnikova, H Reingruber… - Nature …, 2022 - nature.com
Formaldehyde (FA) is a ubiquitous endogenous and environmental metabolite that is thought
to exert cytotoxicity through DNA and DNA-protein crosslinking, likely contributing to the …

Formaldehyde metabolism and its impact on human health

H Reingruber, LB Pontel - Current opinion in toxicology, 2018 - Elsevier
Human health is threatened by exposure to reactive toxins that can damage fundamental
biomolecules such as DNA and proteins. One of these molecules is formaldehyde, the simplest …

Endogenous formaldehyde scavenges cellular glutathione resulting in cytotoxic redox disruption

…, AJ Vesting, I Karakasilioti, H Reingruber… - BioRxiv, 2020 - biorxiv.org
Formaldehyde (FA) is a ubiquitous endogenous and environmental metabolite that is thought
to exert cytotoxicity through DNA and DNA-protein crosslinking. We show here that FA can …

Early redox homeostasis disruption contributes to the differential cytotoxicity of imiquimod on transformed and normal endothelial cells

…, MJ Muñoz, H Reingruber… - Experimental …, 2022 - Wiley Online Library
The off‐label use of imiquimod (IQ) for hemangioma treatment has shown clinical benefits.
We have previously reported a selective direct IQ‐cytotoxic effect on transformed (H5V) vs. …

Differential antitumoral effects between the analogues of calcitriol SG1 and EM1

SM Grioli, MJ Ferronato, DJ Obiol, JA Guevara… - 2017 - ri.conicet.gov.ar
1α,25-dihydroxyvitamin D3 (calcitriol) shows potent growth-inhibi- tory properties on
different cancer cell lines although its hypercal- cemic effects have severely hampered its …

La discriminación un límite para los despidos incausados

CV Reingruber - 2023 - repositorio.21.edu.ar
En la actualidad podemos observar cómo a través del avance de los medios de comunicación
y las redes sociales, las personas, en pleno goce de su libertad de exponer, publicar, …

Toxic effect of formaldehyde: A systematic review

S Dan, M Pant, T Kaur, S Pant - 2020 - philpapers.org
Formaldehyde is one of the potent toxic industrial chemicals that are very commonly used in
various industries, labs, and biological museums, etc. The toxicity of formaldehyde is well-…

[HTML][HTML] Formaldehyde toxicity in age-related neurological dementia

Y Kou, H Zhao, D Cui, H Han, Z Tong - Ageing Research Reviews, 2022 - Elsevier
The primordial small gaseous molecules, such as: NO, CO, H 2 S and formaldehyde (FA)
are present in the brains. Whether FA as well as the other molecules participates in brain …

[PDF][PDF] A Review on the Traditional Methods and Novel Techniques for Detection of Formaldehyde Concentration in Fish

S Deepika, R David, S Salim, J Swathi, DM Varghese… - researchgate.net
Hernán Reingruber, Lucas Blas Pontel,” Formaldehyde metabolism and its impact on human
health, Current Opinion in Toxicology (2018),” Elsevier, volume 9, June 2018, Pages 28-34 …

Age-or lifestyle-induced accumulation of genotoxicity is associated with a generalized shutdown of long gene transcription

O Ibañez-Solé, A Izeta - bioRxiv, 2022 - biorxiv.org
A causative role for DNA damage as a molecular driver of aging has long been advocated.
Transcription-blocking lesions (TBLs) accumulate with age in a stochastic manner. Thus, …