SNARE molecules are the core constituents of the protein machinery that facilitate fusion of
synaptic vesicles with the presynaptic plasma membrane, resulting in the release of …

Society is increasingly exposed to nanoparticles as they are ubiquitous in nature and introduced
as man-made air pollutants and as functional ingredients in cosmetic products as well …

Physiological membrane vesicles are built to separate reaction spaces in a stable manner,
even when they accidentally collide or are kept in apposition by spatial constraints in the cell. …

Neurotransmitter release at the synapse requires fusion of synaptic vesicles with the
presynaptic plasma membrane. SNAREs are the core constituents of the protein machinery …

Over the past 20 years, it has been widely accepted that membrane fusion proceeds via a
hemifusion step before opening of the productive fusion pore. An initial hourglass-shaped lipid …

Membrane fusion in eukaryotic cells mediates the biogenesis of organelles, vesicular traffic
between them, and exo- and endocytosis of important signalling molecules, such as …

The question of how amyloid fibril formation is influenced by surfaces is crucial for a detailed
understanding of the process in vivo. We applied a combination of kinetic experiments and …

Our molecular simulations reveal that wild-type influenza fusion peptides are able to stabilize
a highly fusogenic pre-fusion structure, ie a peptide bundle formed by four or more trans-…

Biological membrane fusion proceeds via an essential topological transition of the two
membranes involved. Known players such as certain lipid species and fusion proteins are …

Coarse-grained force fields (CG FFs) such as the Martini model entail a predefined, fixed set
of Lennard-Jones parameters (building blocks) to model virtually all possible nonbonded …