Pharmacological inhibition of uncontrolled cell growth with small-molecule inhibitors is a
potential strategy for treating glioblastoma multiforme (GBM), the most malignant primary brain …

Intramembrane proteases (IMPs) are localized within lipid bilayers of membranes—either
the cell membrane or membranes of various organelles. Cleavage of substrates often results …

Photoaffinity labeling followed by tandem mass spectrometry is an often used strategy to
identify protein targets of small-molecule drugs or drug candidates, which, under ideal …

Ligand-directed protein labelling allows the introduction of diverse chemical functionalities
onto proteins without the need for genetically encoded tags. Here we report a method for the …

Covalent chemical probes are important tools in chemical biology. They range from post-translational
modification (PTM)-derived metabolic probes, to activity-based probes and …

2-Cyanobenzothiazoles (CBTs) are useful building blocks for: 1) luciferin derivatives for
bioluminescent imaging; and 2) handles for bioorthogonal ligations. A particularly versatile CBT …

Protein kinases, one of the largest enzyme superfamilies, regulate many physiological and
pathological processes. They are drug targets for multiple human diseases, including various …

Chemical methods that allow for the targeted labelling of a specific protein within a complex
biological environment can enable valuable information regarding the structure and function …

Pharmacological inhibition of uncontrolled cell growth with small molecule inhibitors is a
potential strategy against glioblastoma multiforme (GBM), the most malignant primary brain …

… Author Correction: Photocatalytic proximity labelling of MCL-1 by a BH3 ligand Hester A.
Beard, Jacob R. Hauser, Martin Walko , Rachel M. George, Andrew J. …