Focused ultrasound/microbubbles-assisted BBB opening enhances LNP-mediated mRNA delivery to brain
…, D Omata, R Suzuki, K Maruyama, H Mukai… - Journal of Controlled …, 2022 - Elsevier
Messenger RNA (mRNA) medicine has become a new therapeutic approach owing to the
progress in mRNA delivery technology, especially with lipid nanoparticles (LNP). However, …
progress in mRNA delivery technology, especially with lipid nanoparticles (LNP). However, …
Recent advances in lipid nanoparticles for delivery of nucleic acid, mRNA, and gene editing-based therapeutics
H Mukai, K Ogawa, N Kato, S Kawakami - Drug metabolism and …, 2022 - Elsevier
Lipid nanoparticles (LNPs) are becoming popular as a means of delivering therapeutics,
including those based on nucleic acids and mRNA. The mRNA-based coronavirus disease …
including those based on nucleic acids and mRNA. The mRNA-based coronavirus disease …
Macrocyclic peptide-based inhibition and imaging of hepatocyte growth factor
…, M Umitsu, J Takagi, Y Kato, H Mukai… - Nature chemical …, 2019 - nature.com
Activation of hepatocyte growth factor (HGF) by proteolytic processing is triggered in cancer
microenvironments, and subsequent signaling through the MET receptor is involved in …
microenvironments, and subsequent signaling through the MET receptor is involved in …
[HTML][HTML] Stability study of mRNA-lipid nanoparticles exposed to various conditions based on the evaluation between physicochemical properties and their relation with …
…, M Kawaguchi, S Mizukami, M Tsurumaru, H Mukai… - pharmaceutics, 2022 - mdpi.com
Lipid nanoparticles (LNPs) are currently in the spotlight as delivery systems for mRNA
therapeutics and have been used in the Pfizer/BioNTech and Moderna COVID-19 vaccines. mRNA…
therapeutics and have been used in the Pfizer/BioNTech and Moderna COVID-19 vaccines. mRNA…
[HTML][HTML] Synthesis and evaluation of a novel adapter lipid derivative for preparation of cyclic peptide-modified PEGylated liposomes: Application of cyclic RGD peptide
…, L Geng, M Tsurumaru, M Hagimori, H Mukai… - European Journal of …, 2022 - Elsevier
Peptide ligand modified nanoparticles can simply prepared by post-insertion method to mix
pre-formed nanoparticles with peptide-lipid conjugates in an aqueous solution at an optimal …
pre-formed nanoparticles with peptide-lipid conjugates in an aqueous solution at an optimal …
[HTML][HTML] Influence of lipid composition of messenger RNA-loaded lipid nanoparticles on the protein expression via intratracheal administration in mice
L Geng, N Kato, Y Kodama, H Mukai… - International Journal of …, 2023 - Elsevier
Intratracheal (it) administration, which takes advantage of the specific structure of the respiratory
system, can effectively deliver nanoparticles to the lung. Much remains unknown about …
system, can effectively deliver nanoparticles to the lung. Much remains unknown about …
Investigation of enhanced intracellular delivery of nanomaterials modified with novel cell-penetrating zwitterionic peptide-lipid derivatives
…, T Suga, M Umino, A Yamayoshi, H Mukai… - Drug Delivery, 2023 - Taylor & Francis
Functionalized drug delivery systems have been investigated to improve the targetability and
intracellular translocation of therapeutic drugs. We developed high functionality and quality …
intracellular translocation of therapeutic drugs. We developed high functionality and quality …
Development of an apolipoprotein E mimetic peptide–lipid conjugate for efficient brain delivery of liposomes
…, Y Iida, M Matsumoto, S Fumoto, H Arima, H Mukai… - Drug Delivery, 2023 - Taylor & Francis
Liposomes are versatile carriers that can encapsulate various drugs; however, for delivery
to the brain, they must be modified with a targeting ligand or other modifications to provide …
to the brain, they must be modified with a targeting ligand or other modifications to provide …
[HTML][HTML] Induction of liver-resident memory T cells and protection at liver-stage malaria by mRNA-containing lipid nanoparticles
…, JY Jian, T Araki, Y Katagami, H Mukai… - Frontiers in …, 2023 - frontiersin.org
Recent studies have suggested that CD8 + liver-resident memory T (T RM ) cells are crucial
in the protection against liver-stage malaria. We used liver-directed mRNA-containing lipid …
in the protection against liver-stage malaria. We used liver-directed mRNA-containing lipid …
Synthesis of 11C-Radiolabeled Eribulin as a Companion Diagnostics PET Tracer for Brain Glioblastoma
…, S Irie, E Hayashinaka, Y Wada, H Mukai… - Bulletin of the …, 2023 - academic.oup.com
The successful 11 C-radiolabeling of eribulin, an analog of the marine natural product
halichondrin B, and an approved anticancer drug for the treatment of breast cancer and …
halichondrin B, and an approved anticancer drug for the treatment of breast cancer and …