Chromosomal translocations involving the MLL gene are associated with infant acute
lymphoblastic and mixed lineage leukemia. There are a large number of translocation partners of …

Promoter-proximal pausing by initiated RNA polymerase II (Pol II) and regulated release of
paused polymerase into productive elongation has emerged as a major mechanism of …

Deubiquitinating enzymes (DUBs) are proteases that can antagonize ubiquitin-mediated
signaling by disassembling ubiquitin-protein conjugates. How DUBs are regulated in vivo and …

The growth responses of a variety of human intestinal bacteria to partially hydrolyzed guar
gum (PHGG) were investigated in vitro and in vivo. In an in vitro experiment, PHGG …

To identify a novel target for the treatment of heart failure, we examined gene expression in
the failing heart. Among the genes analyzed, Alox15 encoding the protein 12/15 …

We have investigated the effect of glycyrrhetic acid (GR) which is metabolic substance of
glycyrrhizin, on DNA of human hepatoma (HLE), promyelotic leukemia (HL-60) and stomach …

A partially hydrolyzed guar gum preparation(PHGG, average molecular weight: 20,000),
obtained as a water-soluble dietary fiber by digestion of guar gum with ƒÀ-D-endomannanase, …

Background— Dilated cardiomyopathy (DCM), characterized by dilatation and dysfunction
of the left ventricle, is an important cause of heart failure. Many mutations in various genes, …

Wnt signaling pathways are tightly regulated by ubiquitination, and dysregulation of these
pathways promotes tumorigenesis. It has been reported that the ubiquitin ligase RNF43 plays …

Frequent mutation of the tumour suppressor RNF43 is observed in many cancers, particularly
colon malignancies. RNF43, an E3 ubiquitin ligase, negatively regulates Wnt signalling by …