M cells located in the follicle-associated epithelium of Peyer's patches (PP) are shown to be
the principal sites for the sampling of gut luminal antigens. Thus, PP have long been …

Mast cells are known effector cells in allergic and inflammatory diseases, but their precise
roles in intestinal inflammation remain unknown. Here we show that activation of mast cells in …

Background After endoscopic submucosal dissection (ESD) of early gastric cancer (EGC),
patients are at high risk for synchronous or metachronous multiple gastric cancers. Objective …

Colonic epithelial cells are covered by thick inner and outer mucus layers 1 , 2 . The inner
mucus layer is free of commensal microbiota, which contributes to the maintenance of gut …

The indigenous bacteria create natural cohabitation niches together with mucosal Abs in
the gastrointestinal (GI) tract. Here we report that opportunistic bacteria, largely Alcaligenes …

Background Reliable biomarkers for monitoring disease activity have not been clinically
established in ulcerative colitis (UC). This study aimed to investigate whether levels of serum …

Objective To identify a novel serum biomarker of disease activity in inflammatory autoimmune
disorders. Methods Sera obtained from rheumatoid arthritis (RA) patients before and after …

Background and study aims: The safety and efficacy of endoscopic submucosal dissection (ESD)
for superficial esophageal neoplasms (SENs) have not been evaluated in a multicenter …

Mesenchymal stem cells (MSCs) are attractive cell sources in regenerative medicine. We
examined the effects of topical MSCs implantation on an experimental model of inflammatory …

T cell activation through the T cell receptor (TCR) is subsequently modified by secondary
signals that are either stimulatory or inhibitory. We show that CEACAM1 adhesion molecule …