With the rapid development of alternative methods based on the spirit of animal welfare, the
publications of animal studies evaluating endpoints such as cancer have been extremely …

… Carcinogenicity and Chronic Toxicity after Inhalation Exposure of Rats and Mice to N,N-Dimethylformamide:
Hideki Senoh, et al. Japan Bioassay Research Center—Carcinogenicity …

Background Most toxicological studies on titanium dioxide (TiO 2 ) particles to date have
concentrated on carcinogenicity and acute toxicity, with few studies focusing of pneumoconiosis…

Background In Japan, six workers handling cross-linked water-soluble acrylic acid polymer (CWAAP)
at a chemical plant suffered from lung diseases, including fibrosis, interstitial …

The carcinogenicity and chronic toxicity of acrolein was examined by whole body inhalation
to groups of 50 F344/DuCrlCrlj rats and 50 B6D2F1/Crlj mice of both sexes for two years. …

Subchronic oral toxicity of 1, 4-dioxane was examined by administering 1, 4-dioxane in
drinking water at 6 different concentrations of 0 (control), 640, 1,600, 4,000, 10,000 or 25,000 …

In this review, we focus on the rat pulmonary carcinogenicity of two solid substances, fibrous
multi-walled carbon nanotube (MWCNT) and particulate indium tin oxide (ITO). Inhalation …

Objectives In this study, we focused on the qualitative and quantitative differences of the
lung lesions induced by single or multiple intratracheal administration of nickel oxide …

Carcinogenicity and Chronic Toxicity in Rats and Mice Exposed by Inhalation to 1,2‐Dichloroethane
for Two Years: Kasuke Nagano, et al. Japan Bioassay Research Center, Japan …

Background Recently in Japan, six workers at a chemical plant that manufactures resins
developed interstitial lung diseases after being involved in loading and packing cross-linked …