Multi-ancestry genetic study of type 2 diabetes highlights the power of diverse populations for discovery and translation
We assembled an ancestrally diverse collection of genome-wide association studies (GWAS)
of type 2 diabetes (T2D) in 180,834 affected individuals and 1,159,055 controls (48.9% non…
of type 2 diabetes (T2D) in 180,834 affected individuals and 1,159,055 controls (48.9% non…
Refining the accuracy of validated target identification through coding variant fine-mapping in type 2 diabetes
We aggregated coding variant data for 81,412 type 2 diabetes cases and 370,832 controls
of diverse ancestry, identifying 40 coding variant association signals (P < 2.2 × 10 −7 ); of …
of diverse ancestry, identifying 40 coding variant association signals (P < 2.2 × 10 −7 ); of …
Trans-ethnic meta-regression of genome-wide association studies accounting for ancestry increases power for discovery and improves fine-mapping resolution
Trans-ethnic meta-analysis of genome-wide association studies (GWAS) across diverse
populations can increase power to detect complex trait loci when the underlying causal variants …
populations can increase power to detect complex trait loci when the underlying causal variants …
[HTML][HTML] Genome-wide association study of coronary artery disease in the Japanese
…, N Awata, K Ohnaka, M Nakatochi, H Kitajima… - European journal of …, 2012 - nature.com
A new understanding of the genetic basis of coronary artery disease (CAD) has recently
emerged from genome-wide association (GWA) studies of common single-nucleotide …
emerged from genome-wide association (GWA) studies of common single-nucleotide …
[HTML][HTML] A genome-wide association study of a coronary artery disease risk variant
…, M Nakatochi, T Matsubara, H Kitajima… - Journal of human …, 2013 - nature.com
Although over 30 common genetic susceptibility loci have been identified to be independently
associated with coronary artery disease (CAD) risk through genome-wide association …
associated with coronary artery disease (CAD) risk through genome-wide association …
Protein-coding variants implicate novel genes related to lipid homeostasis contributing to body-fat distribution
…, SLR Kardia, F Karpe, F Kee, H Kitajima… - Nature …, 2019 - nature.com
Body-fat distribution is a risk factor for adverse cardiovascular health consequences. We
analyzed the association of body-fat distribution, assessed by waist-to-hip ratio adjusted for …
analyzed the association of body-fat distribution, assessed by waist-to-hip ratio adjusted for …
Trans-ancestry genetic study of type 2 diabetes highlights the power of diverse populations for discovery and translation
We assembled an ancestrally diverse collection of genome-wide association studies of type
2 diabetes (T2D) in 180,834 cases and 1,159,055 controls (48.9% non-European descent). …
2 diabetes (T2D) in 180,834 cases and 1,159,055 controls (48.9% non-European descent). …
[HTML][HTML] Bone mineral density and risk of type 2 diabetes and coronary heart disease: a Mendelian randomization study
…, A Mahajan, B Kulohoma, H Kitajima… - Wellcome Open …, 2017 - ncbi.nlm.nih.gov
Background: Observational studies have demonstrated that increased bone mineral density
is associated with a higher risk of type 2 diabetes (T2D), but the relationship with risk of …
is associated with a higher risk of type 2 diabetes (T2D), but the relationship with risk of …
DNA methylation of the Klf14 gene region in whole blood cells provides prediction for the chronic inflammation in the adipose tissue
C Iwaya, H Kitajima, K Yamamoto, Y Maeda… - Biochemical and …, 2018 - Elsevier
Krüppel-Like Factor 14 (KLF14) gene, which appears to be a master regulator of gene
expression in the adipose tissue and have previously been associated with BMI and Type 2 …
expression in the adipose tissue and have previously been associated with BMI and Type 2 …
Identification of a Glutamic Acid Repeat Polymorphism of ALMS1 as a Novel Genetic Risk Marker for Early-Onset Myocardial Infarction by Genome-Wide Linkage …
…, JE Park, S Tada-Oikawa, H Kitajima… - Circulation …, 2013 - Am Heart Assoc
Background— Myocardial infarction (MI) is a leading cause of death worldwide. Given that a
family history is an independent risk factor for coronary artery disease, genetic variants are …
family history is an independent risk factor for coronary artery disease, genetic variants are …