Prophages are associated with extensive CRISPR–Cas auto-immunity

FL Nobrega, H Walinga, BE Dutilh… - Nucleic acids …, 2020 - academic.oup.com
CRISPR–Cas systems require discriminating self from non-self DNA during adaptation and
interference. Yet, multiple cases have been reported of bacteria containing self-targeting …

[PDF][PDF] Genomic characterization of four novel bacteriophages infecting the clinical pathogen Klebsiella pneumoniae

…, T Van Rossum, S Hagedoorn, H Walinga… - DNA …, 2021 - academic.oup.com
Bacteriophages are an invaluable source of novel genetic diversity. Sequencing of phage
genomes can reveal new proteins with potential uses as biotechnological and medical tools, …

Prophages are associated with extensive, tolerated CRISPR-Cas auto-immunity

FL Nobrega, H Walinga, BE Dutilh, SJJ Brouns - BioRxiv, 2020 - biorxiv.org
CRISPR-Cas systems require discriminating self from non-self DNA during adaptation and
interference. Yet, multiple cases have been reported of bacteria containing self-targeting …

[PDF][PDF] CRISPR-based DNA and RNA detection with liquid phase separation

WK Spoelstra, JM Jacques, FL Nobrega… - Preprint at https://www …, 2018 - brounslab.org
The RNA-guided CRISPR endonucleases Cas12a and Cas13a allow detection of specific
DNA or RNA sequences in molecular diagnostics applications. Here, we present a novel …

Modeling of a compliant force distribution mechanism: For a deforming hydrostatic bearing

J van Willigen - 2019 - repository.tudelft.nl
Hydrostatic bearings are well known for having low friction and low wear in combination with
high loading capacity.Traditionally, the running surfaces for a hydrostatic bearing are plane, …

[PDF][PDF] CRISPR-based DNA and RNA detection with liquid-liquid phase separation

WK Spoelstra, JM Jacques, R Gonzalez-Linares… - Biophysical …, 2021 - cell.com
The ability to detect specific nucleic acid sequences allows for a wide range of applications
such as the identification of pathogens, clinical diagnostics, and genotyping. CRISPR-Cas …

Developing a deep learning pipeline for automated salmon welfare analysis by respiration frequency

EB Høgstedt - 2023 - ntnuopen.ntnu.no
Salmon farming is becoming increasingly important in the global food chain, which necessitates
a deep understanding of how internal salmon states relevant for production yield and …