Next generation sequencing (NGS) is challenged by structural and copy number variations
larger than the typical read length of several hundred bases. Third-generation sequencing …

The interactions between antibodies, SARS-CoV-2 and immune cells contribute to the
pathogenesis of COVID-19 and protective immunity. To understand the differences between …

DNA damage and repair are linked to fundamental biological processes such as metabolism,
disease, and aging. Single-strand lesions are the most abundant form of DNA damage; …

We report on the development of a methylation analysis workflow for optical detection of
fluorescent methylation profiles along chromosomal DNA molecules. In combination with …

The epigenetic mark 5-hydroxymethylcytosine (5-hmC) is a distinct product of active DNA
demethylation that is linked to gene regulation, development, and disease. In particular, 5-hmC …

Mapping DNA damage and its repair has immense potential in understanding environmental
exposures, their genotoxicity, and their impact on human health. Monitoring changes in …

Knowing the amount and type of DNA damage is of great significance for a broad range of
clinical and research applications. However, existing methods are either lacking in their ability …

Variations in the genetic code, from single point mutations to large structural or copy number
alterations, influence susceptibility, onset, and progression of genetic diseases and tumor …

DNA combing is a widely used method for stretching and immobilising DNA molecules on a
surface. Fluorescent labelling of genomic information enables high-resolution optical …

Motivation While promoter methylation is associated with reinforcing fundamental tissue
identities, the methylation status of distant enhancers was shown by genome-wide association …