Background The mouse inbred line C57BL/6J is widely used in mouse genetics and its
genome has been incorporated into many genetic reference populations. More recently large …

The function of the majority of genes in the mouse and human genomes remains unknown.
The mouse embryonic stem cell knockout resource provides a basis for the characterization …

Understanding mammalian genetic systems is predicated on the determination of the
relationship between genetic variation and phenotype. Several international programmes are …

The broad aim of biomedical science in the postgenomic era is to link genomic and
phenotype information to allow deeper understanding of the processes leading from genomic …

Background Recent developments in CRISPR/Cas9 genome-editing tools have facilitated
the introduction of precise alleles, including genetic intervals spanning several kilobases, …

Comprehensive phenotyping will be required to reveal the pleiotropic functions of a gene
and to uncover the wider role of genetic loci within diverse biological systems. The challenge …

Recent developments in CRISPR/Cas9 genome editing tools have facilitated the introduction
of more complex alleles, often spanning genetic intervals of several kilobases, directly into …

The International Knockout Mouse Consortium (IKMC) developed high throughput gene
trapping and gene targeting pipelines that produced mostly conditional mutations of more than …

There are now a number of microcomputer packages intended for almost every library routine
and application, although in some cases the choice is limited. The principal features of …

With the completion of the human genome sequence (International Human Genome Sequencing
Consortium, 2001)[1], mammalian genetics is set to enter a new era of discovery. For …