Background Homologous recombination deficiency (HRD) is a phenotype that is
characterized by the inability of a cell to effectively repair DNA double-strand breaks using the …

In nontransformed bovine mammary epithelial cells, the intrinsic apoptosis inducer anisomycin
(ANS) induces IGFBP-3 expression and nuclear localization and knockdown of IGFBP-3 …

Invasive lobular breast cancer (ILC) is an understudied malignancy with distinct clinical,
pathological, and molecular features that distinguish it from the more common invasive ductal …

To influence energy homeostasis and reproduction, 17β-estradiol (E2) controls the arcuate
nucleus (ARC) through multiple receptor-mediated mechanisms, but primarily via estrogen …

Antiretroviral therapies (ARTs) benefit millions with human immunodeficiency virus.
However, concerns about subsequent weight gain and related metabolic complications have …

PURPOSE The onset of the COVID-19 pandemic created major disruptions in the conduct
of cancer clinical trials. In response, regulators and sponsors allowed modifications to …

Breast tumors overexpressing human epidermal growth factor receptor (HER2) confer intrinsic
resistance to endocrine therapy (ET), and patients with HER2/estrogen receptor–positive (…

Including patient advocates in basic cancer research ensures that breast cancer research is
intentional, supports effective communication with broader audiences, and directly connects …

PURPOSE Using patient-reported outcomes (PROs) provides important insights from the
patient's perspective and can be valuable to monitor and manage treatment-related adverse …

e12520 Background: There has been substantial progress in treatment of metastatic HER2+
breast cancer, unfortunately, treatment progression of the disease is universal. Palbociclib …