The trimeric human immunodeficiency virus type 1 (HIV-1) envelope glycoprotein (Env) spike
is a molecular machine that mediates virus entry into host cells and is the sole target for …

Binding to the CD4 receptor induces conformational changes in the human immunodeficiency
virus (HIV-1) gp120 exterior envelope glycoprotein. These changes allow gp120 to bind …

Phosphatidylserine (PS) receptors enhance infection of many enveloped viruses through
virion-associated PS binding that is termed apoptotic mimicry. Here we show that this broadly …

Sexual transmission of human immunodeficiency virus type 1 (HIV-1) across mucosal
barriers is responsible for the vast majority of new infections. This relatively inefficient process …

Human immunodeficiency virus (HIV-1) enters cells following sequential activation of the
high-potential-energy viral envelope glycoprotein trimer by target cell CD4 and coreceptor. HIV-…

The mature envelope glycoprotein (Env) spike on the surface of human immunodeficiency
virus type 1 (HIV-1) virions is derived by proteolytic cleavage of a trimeric gp160 glycoprotein …

The envelope glycoproteins (Envs) of HIV-1 are embedded in the cholesterol-rich lipid
membrane of the virus. Chemical depletion of cholesterol from HIV-1 particles inactivates their …

Binding to the primary receptor CD4 induces conformational changes in the human
immunodeficiency virus type 1 (HIV-1) gp120 envelope glycoprotein that allow binding to the …

The HIV-1 envelope glycoproteins (Env) undergo conformational changes upon interaction
of the gp120 exterior glycoprotein with the CD4 receptor. The gp120 inner domain …

Efforts to prevent human immunodeficiency virus type 1 (HIV-1) infection would benefit from
understanding the factors that govern virus neutralization by antibodies. We present a …