Introduction Monocytes circulate in the bloodstream for up to 3 to 5 days. Concomitantly,
immunological imprinting of either tolerance (immunosuppression) or trained immunity (innate …

The use of two kinase inhibitors (2i) enables derivation of mouse embryonic stem cells (ESCs)
in the pluripotent ground state. Using whole-genome bisulfite sequencing (WGBS), we …

Introduction Blood production in humans culminates in the daily release of around 10 11
cells into the circulation, mainly platelets and red blood cells. All blood cells originate from a …

Kidney tumours are among the most common solid tumours in children, comprising distinct
subtypes differing in many aspects, including cell-of-origin, genetics, and pathology. Pre-…

Background During early embryonic development, one of the two X chromosomes in mammalian
female cells is inactivated to compensate for a potential imbalance in transcript levels …

The blood group Vel was discovered 60 years ago 1 , but the underlying gene is unknown.
Individuals negative for the Vel antigen are rare and are required for the safe transfusion of …

Background Next generation sequencing technologies allow to obtain at low cost the
genomic sequence information that currently lacks for most economically and ecologically …

Background The development of second generation sequencing methods has enabled large
scale DNA variation studies at moderate cost. For the high throughput discovery of single …

Background The chicken (Gallus gallus), like most avian species, has a very distinct
karyotype consisting of many micro- and a few macrochromosomes. While it is known that …

Identifying genes that underlie ecological traits will open exiting possibilities to study gene–environment
interactions in shaping phenotypes and in measuring natural selection on genes…