NUDT15 polymorphisms alter thiopurine metabolism and hematopoietic toxicity
…, H Inaba, CH Pui, MV Relling, A Manabe, H Hori… - Nature …, 2016 - nature.com
Widely used as anticancer and immunosuppressive agents, thiopurines have narrow therapeutic
indices owing to frequent toxicities, partly explained by TPMT genetic polymorphisms. …
indices owing to frequent toxicities, partly explained by TPMT genetic polymorphisms. …
The genetic basis and cell of origin of mixed phenotype acute leukaemia
…, T Lammens, B De Moerloose, D Catchpoole, H Hori… - Nature, 2018 - nature.com
Mixed phenotype acute leukaemia (MPAL) is a high-risk subtype of leukaemia with myeloid
and lymphoid features, limited genetic characterization, and a lack of consensus regarding …
and lymphoid features, limited genetic characterization, and a lack of consensus regarding …
Massively parallel variant characterization identifies NUDT15 alleles associated with thiopurine toxicity
…, S Bhatia, MV Relling, M Kato, H Hori… - Proceedings of the …, 2020 - National Acad Sciences
As a prototype of genomics-guided precision medicine, individualized thiopurine dosing
based on pharmacogenetics is a highly effective way to mitigate hematopoietic toxicity of this …
based on pharmacogenetics is a highly effective way to mitigate hematopoietic toxicity of this …
Management of adult and paediatric acute lymphoblastic leukaemia in Asia: resource-stratified guidelines from the Asian Oncology Summit 2013
Survival for adults and children with acute lymphoblastic leukaemia has risen substantially
in recent years because use of improved risk-directed treatments and supportive care has …
in recent years because use of improved risk-directed treatments and supportive care has …
The effects of inherited NUDT15 polymorphisms on thiopurine active metabolites in Japanese children with acute lymphoblastic leukemia
…, K Schmiegelow, JJ Yang, H Hori - Pharmacogenetics …, 2017 - journals.lww.com
Thiopurines [eg mercaptopurine (MP)] are widely used as chemotherapeutic agents in the
treatment of pediatric acute lymphoblastic leukemia with dose-limiting hematopoietic toxicity. …
treatment of pediatric acute lymphoblastic leukemia with dose-limiting hematopoietic toxicity. …
Effect of long‐term depletion of plasma methionine on the growth and survival of human brain tumor xenografts in athymic mice
DM Kokkinakis, SC Schold Jr, H Hori, T Nobori - 1997 - Taylor & Francis
Depletion of plasma methionine is expected to inhibit or reverse growth of methionine‐dependent
tumors; however, modulation of methionine and other sulfur amino acids is not a trivial …
tumors; however, modulation of methionine and other sulfur amino acids is not a trivial …
IKZF1 deletion is associated with a poor outcome in pediatric B‐cell precursor acute lymphoblastic leukemia in Japan
…, Y Hashii, K Matsumoto, H Kawasaki, H Hori… - Cancer …, 2013 - Wiley Online Library
Genetic alterations of Ikaros family zinc finger protein 1 ( IKZF 1), point mutations in Janus
kinase 2 ( JAK 2), and overexpression of cytokine receptor‐like factor 2 ( CRLF 2) were …
kinase 2 ( JAK 2), and overexpression of cytokine receptor‐like factor 2 ( CRLF 2) were …
[HTML][HTML] Gut microbiota signature of pathogen-dependent dysbiosis in viral gastroenteritis
…, D Kushitor, EY Bonney, M Adachi, H Hori… - Scientific Reports, 2021 - nature.com
Acute gastroenteritis associated with diarrhea is considered a serious disease in Africa and
South Asia. In this study, we examined the trends in the causative pathogens of diarrhea and …
South Asia. In this study, we examined the trends in the causative pathogens of diarrhea and …
[HTML][HTML] Magnetic resonance-guided focused ultrasound for mesial temporal lobe epilepsy: a case report
…, H Hori, M Sumi, S Horisawa, T Taira, T Hori - BMC neurology, 2020 - Springer
Background We report the first case of transcranial magnetic resonance-guided focused
ultrasound (MRgFUS) for mesial temporal lobe epilepsy (MTLE). Case presentation The target …
ultrasound (MRgFUS) for mesial temporal lobe epilepsy (MTLE). Case presentation The target …
AGB1 and PMR5 Contribute to PEN2-Mediated Preinvasion Resistance to Magnaporthe oryzae in Arabidopsis thaliana
…, Y Houjyou, T Komatsu, H Hori… - Molecular plant …, 2009 - Am Phytopath Society
Rice blast, caused by Magnaporthe oryzae, is a devastating disease of rice (Oryza sativa).
The mechanisms involved in resistance of rice to blast have been studied extensively and the …
The mechanisms involved in resistance of rice to blast have been studied extensively and the …