The diversity of glycerophospholipid species in cellular membranes is immense and affects
various biological functions. Glycerol-3-phosphate acyltransferases (GPATs) and …

Extracellular vesicles (EVs) are classified as large EVs (l-EVs, or microvesicles) and small
EVs (s-EVs, or exosomes). S-EVs are thought to be generated from endosomes through a …

Food-borne trans-fatty acids (TFAs) are mainly produced as byproducts during food manufacture.
Recent epidemiological studies have revealed that TFA consumption is a major risk …

Phospholipase A 1 (PLA 1 ) is an enzyme that cleaves an ester bond at the sn-1 position of
glycerophospholipids, producing a free fatty acid and a lysophospholipid. PLA 1 activities …

The fatty acid composition of phosphatidylethanolamine (PE) determines cellular metabolism,
oxidative stress, and inflammation. However, our understanding of how cells regulate PE …

The human adiponectin receptors, AdipoR1 and AdipoR2, are key anti-diabetic molecules.
We previously reported the crystal structures of human AdipoR1 and AdipoR2, revealing that …

GPR34 is a recently identified G-protein coupled receptor, which has an immunomodulatory
role and recognizes lysophosphatidylserine (LysoPS) as a putative ligand. Here, we report …

Skeletal muscle consists of both fast- and slow-twitch fibers. Phospholipids are important
structural components of cellular membranes, and the diversity of their fatty acid composition …

Phospholipids in the membrane consist of diverse pairs of fatty acids bound to a glycerol
backbone. The biological significance of the diversity, however, remains mostly unclear. Part of …

Lysophospholipid acyltransferases (LPLATs) incorporate a fatty acid into the hydroxyl group
of lysophospholipids (LPLs) and are critical for determining the fatty acid composition of …