Animal models of human diseases that accurately recapitulate clinical pathology are
indispensable for understanding molecular mechanisms and advancing preclinical studies. The …

Since 1995, more than 100 transgenic (Tg) mouse models of Alzheimer’s disease (AD)
have been generated in which mutant amyloid precursor protein (APP) or APP/presenilin 1 (PS1) …

The major genetic cause of frontotemporal dementia and amyotrophic lateral sclerosis is a G
4 C 2 repeat expansion in C9ORF72. Efforts to combat neurodegeneration associated with “…

The occurrence of repeat-associated non-ATG (RAN) translation, an atypical form of translation
of expanded repeats that results in the synthesis of homopolymeric expansion proteins, …

Neuronal inclusions of poly(GA), a protein unconventionally translated from G 4 C 2 repeat
expansions in C9ORF72, are abundant in patients with frontotemporal dementia (FTD) and …

Inclusions of Tar DNA- binding protein 43 (TDP-43) are a pathological hallmark of
amyotrophic lateral sclerosis (ALS) and frontotemporal lobar degeneration with TDP-43-positive …

TAR DNA-binding protein-43 (TDP-43) is the principal component of ubiquitinated inclusions
in amyotrophic lateral sclerosis (ALS) and the most common pathological subtype of …

In cortical regions of brains from individuals with preclinical or clinical Alzheimer's disease (AD),
extracellular β-amyloid (Aβ) deposition precedes the aggregation of pathological …

Amyotrophic lateral sclerosis is a fatal neurodegenerative disease characterized by
progressive motoneuron loss. Redistribution of transactive response deoxyribonucleic acid-binding …

Increased oxidative damage is a prominent and early feature in Alzheimer disease. We
previously crossed Alzheimer disease transgenic (APPsw) model mice with α-tocopherol transfer …