Host factors required for viral replication are ideal drug targets because they are less likely
than viral proteins to mutate under drug-mediated selective pressure. Although genome-wide …

Tardigrades, also known as water bears, are small aquatic animals. Some tardigrade
species tolerate almost complete dehydration and exhibit extraordinary tolerance to various …

In the mammalian circadian clockwork, CRY1 and CRY2 repressor proteins are regulated
by posttranslational modifications for temporally coordinated transcription of clock genes. …

Formation of one procentriole next to each pre-existing centriole is essential for centrosome
duplication, robust bipolar spindle assembly and maintenance of genome integrity. However…

Herpes simplex virus-1 (HSV-1), the prototype of the α-herpesvirus family, causes life-long
infections in humans. Although generally associated with various mucocutaneous diseases, …

Toll-like receptors (TLRs) 3, 7, and 9 recognize microbial nucleic acids in endolysosomes
and initiate innate and adaptive immune responses. TLR7/9 in dendritic cells (DCs) also …

The cell cycle transition from interphase into mitosis is best characterized by the appearance
of condensed chromosomes that become microscopically visible as thread-like structures in …

Many long noncoding RNAs (lncRNAs) are reported to be dysregulated in human cancers
and play critical roles in tumor development and progression. Furthermore, it has been …

The development of cancer is driven not only by genetic mutations but also by epigenetic
alterations. Here, we show that TET1-mediated production of 5-hydroxymethylcytosine (5hmC) …

To identify candidate royal jelly (RJ) proteins that might affect the physiologic status of
honeybee colony members, we used shotgun proteomics to comprehensively identify the RJ …