[HTML][HTML] Narcolepsy risk loci outline role of T cell autoimmunity and infectious triggers in narcolepsy

…, J Winkelmann, T Miyagawa, H Toyoda… - Nature …, 2023 - nature.com
Narcolepsy type 1 (NT1) is caused by a loss of hypocretin/orexin transmission. Risk factors
include pandemic 2009 H1N1 influenza A infection and immunization with Pandemrix®. Here…

Anti-Tribbles homolog 2 autoantibodies in Japanese patients with narcolepsy

H Toyoda, S Tanaka, T Miyagawa, Y Honda… - Sleep, 2010 - academic.oup.com
Study Objectives: Narcolepsy is a sleep disorder characterized by excessive daytime sleepiness
and cataplexy. The association with human leukocyte antigen (HLA)-DQB1*0602 and T-…

A polymorphism in CCR1/CCR3 is associated with narcolepsy

H Toyoda, T Miyagawa, A Koike, T Kanbayashi… - Brain, behavior, and …, 2015 - Elsevier
Etiology of narcolepsy–cataplexy involves multiple genetic and environmental factors. While
the human leukocyte antigen (HLA)-DRB1*15:01-DQB1*06:02 haplotype is strongly …

[HTML][HTML] Sensitivity to gene dosage and gene expression affects genes with copy number variants observed among neuropsychiatric diseases

M Yamasaki, T Makino, SS Khor, H Toyoda… - BMC Medical …, 2020 - Springer
Background Copy number variants (CNVs) have been reported to be associated with diseases,
traits, and evolution. However, it is hard to determine which gene should have priority as …

New susceptibility variants to narcolepsy identified in HLA class II region

T Miyagawa, H Toyoda, A Hirataka… - Human molecular …, 2015 - academic.oup.com
Narcolepsy, a sleep disorder characterized by excessive daytime sleepiness, cataplexy and
rapid eye movement sleep abnormalities, is tightly associated with human leukocyte antigen …

Cooling history of some Antarctic ureilites

…, H Takeda, H Toyoda - Journal of Geophysical …, 1985 - Wiley Online Library
To obtain some constraints on the cooling histories of ureilites, we have studied the
chemical zoning of olivines and the compositional variations of pyroxenes in the PCA82506, …

Increased plasma IL-6, IL-8, TNF-alpha, and G-CSF in Japanese narcolepsy

S Tanaka, M Honda, H Toyoda, T Kodama - Human immunology, 2014 - Elsevier
Narcolepsy is a chronic hypersomnia involving excessive daytime sleepiness and cataplexy.
Some susceptibility genes and environmental factors suggest that post-infectious …

[HTML][HTML] Genome-wide association study of HLA-DQB1* 06: 02 negative essential hypersomnia

SS Khor, T Miyagawa, H Toyoda, M Yamasaki… - PeerJ, 2013 - peerj.com
Essential hypersomnia (EHS), a sleep disorder characterized by excessive daytime sleepiness,
can be divided into two broad classes based on the presence or absence of the HLA-…

[HTML][HTML] Evaluation of polygenic risks for narcolepsy and essential hypersomnia

M Yamasaki, T Miyagawa, H Toyoda, SS Khor… - Journal of human …, 2016 - nature.com
In humans, narcolepsy is a sleep disorder that is characterized by sleepiness, cataplexy and
rapid eye movement (REM) sleep abnormalities. Essential hypersomnia (EHS) is another …

[HTML][HTML] An association analysis of HLA-DQB1 with narcolepsy without cataplexy and idiopathic hypersomnia with/without long sleep time in a Japanese population

T Miyagawa, H Toyoda, T Kanbayashi… - Human Genome …, 2015 - nature.com
Narcolepsy without cataplexy (NA w/o CA)(narcolepsy type 2) is a lifelong disorder characterized
by excessive daytime sleepiness and rapid eye movement (REM) sleep abnormalities, …