User profiles for Hiroshi Horiuchi

Hiroshi Horiuchi

Verified email at shinshu-u.ac.jp
Cited by 5619

Carbon nanotubes with high bone‐tissue compatibility and bone‐formation acceleration effects

…, K Nakamura, N Ishigaki, H Yamazaki, H Horiuchi… - Small, 2008 - Wiley Online Library
Carbon nanotubes (CNTs) have been used in various fields as composites with other substances
or alone to develop highly functional materials. CNTs hold great interest with respect to …

A biodegradable polymer as a cytokine delivery system for inducing bone formation

N Saito, T Okada, H Horiuchi, N Murakami… - Nature …, 2001 - nature.com
Bone morphogenetic proteins (BMPs) that have the potential to elicit new bone in vivo have
been used in a tissue-engineering approach for the repair of bone injuries and bone defects. …

Reducing the risk of infection in the elderly by dietary intake of yoghurt fermented with Lactobacillus delbrueckii ssp. bulgaricus OLL1073R-1

S Makino, S Ikegami, A Kume, H Horiuchi… - British Journal of …, 2010 - cambridge.org
Immune senescence potentially leads to an increased risk of infections. It is desirable to
augment the immune system and protect against infections by daily consumption of …

[HTML][HTML] Interleukin-1β induces blood–brain barrier disruption by downregulating sonic hedgehog in astrocytes

Y Wang, S Jin, Y Sonobe, Y Cheng, H Horiuchi… - PloS one, 2014 - journals.plos.org
The blood–brain barrier (BBB) is composed of capillary endothelial cells, pericytes, and
perivascular astrocytes, which regulate central nervous system homeostasis. Sonic hedgehog (…

Osteoprotegerin regulates bone formation through a coupling mechanism with bone resorption

…, S Matsuura, M Mogi, H Nakamura, H Horiuchi… - …, 2003 - academic.oup.com
Deficiency of osteoprotegerin (OPG), a soluble decoy receptor for receptor activator of
nuclear factor-κB ligand (RANKL), in mice induces osteoporosis caused by enhanced bone …

Poor bone quality or hip structure as risk factors affecting survival of total-hip arthroplasty

S Kobayashi, N Saito, H Horiuchi, R Iorio, K Takaoka - The Lancet, 2000 - thelancet.com
Background The principal long-term complication after total hip arthroplasty (THA) has been
aseptic fixation failure. Many hip prostheses and operative techniques have been …

Microglia enhance synapse activity to promote local network synchronization

R Akiyoshi, H Wake, D Kato, H Horiuchi, R Ono… - eneuro, 2018 - eneuro.org
Microglia are highly motile immunoreactive cells that play integral roles in the response to
brain infection and damage, and in the progression of various neurological diseases. During …

CCL11 enhances excitotoxic neuronal death by producing reactive oxygen species in microglia

B Parajuli, H Horiuchi, T Mizuno, H Takeuchi… - Glia, 2015 - Wiley Online Library
The chemokine CCL11 (also known as eotaxin‐1) is a potent eosinophil chemoattractant
that mediates allergic diseases such as asthma, atopic dermatitis, and inflammatory bowel …

[HTML][HTML] Fingolimod phosphate attenuates oligomeric amyloid β–induced neurotoxicity via increased brain-derived neurotrophic factor expression in neurons

Y Doi, H Takeuchi, H Horiuchi, T Hanyu… - PloS one, 2013 - journals.plos.org
The neurodegenerative processes that underlie Alzheimer's disease are mediated, in part,
by soluble oligomeric amyloid β, a neurotoxic protein that inhibits hippocampal long-term …

Fingolimod increases brain-derived neurotrophic factor levels and ameliorates amyloid β-induced memory impairment

…, H Mizoguchi, H Takeuchi, H Horiuchi… - Behavioural brain …, 2014 - Elsevier
Alzheimer's disease is a progressive neurodegenerative disorder. Amyloid β, a neurotoxic
protein, causes disruption of hippocampal synaptic plasticity, and induces cognitive …