Although embryonic stem (ES) cell–like induced pluripotent stem (iPS) cells have potential
therapeutic applications in humans, they are also useful for creating genetically modified …

The common marmoset (Callithrix jacchus) is increasingly attractive for use as a non-human
primate animal model in biomedical research. It has a relatively high reproduction rate for a …

To overcome the limitations of existing models, we developed a novel experimental in vivo
platform for replacing mouse liver with functioning human liver tissue. To do this, a herpes …

Experimental studies of Plasmodium parasites that infect humans are restricted by their host
specificity. Humanized mice offer a means to overcome this and further provide the …

The successful establishment of human embryonic stem cell (hESC) lines has inaugurated a
new era in regenerative medicine by facilitating the transplantation of differentiated ESCs to …

The development of animal models that mimic human allergic responses is crucial to study
the pathophysiology of disease and to generate new therapeutic methodologies. Humanized …

Background & Aims Although the tumor microenvironment plays an important role in tumor
growth, it is not fully understood what role hepatic stellate cells (HSCs) play in the …

The MHC class I chain-related MICA molecule is a stress-induced, highly polymorphic,
epithelia-specific, membrane-bound glycoprotein interacting with the activating NK cell receptor …

Species differences exist in terms of drug oxidation activities, which are mediated mainly by
cytochrome P450 (P450) enzymes. To overcome the problem of species extrapolation, …

Unlike protein-coding genes, the majority of human long non-coding RNAs (lncRNAs) are
considered non-conserved. Although lncRNAs have been shown to function in diverse …