[PDF][PDF] Notch inhibition induces cochlear hair cell regeneration and recovery of hearing after acoustic trauma
Hearing loss due to damage to auditory hair cells is normally irreversible because mammalian
hair cells do not regenerate. Here, we show that new hair cells can be induced and can …
hair cells do not regenerate. Here, we show that new hair cells can be induced and can …
Proinflammatory cytokines expression in noise‐induced damaged cochlea
Recent studies have showed that inflammatory responses occur in inner ear under various
damaging conditions including noise‐overstimulation. We evaluated the time‐dependent …
damaging conditions including noise‐overstimulation. We evaluated the time‐dependent …
Visualization of peripheral nerve degeneration and regeneration: monitoring with diffusion tensor tractography
We applied diffusion tensor tractography (DTT), a recently developed MRI technique that
reveals the microstructures of tissues based on its ability to monitor the random movements of …
reveals the microstructures of tissues based on its ability to monitor the random movements of …
[HTML][HTML] The long non-coding RNA nuclear-enriched abundant transcript 1_2 induces paraspeckle formation in the motor neuron during the early phase of …
Y Nishimoto, S Nakagawa, T Hirose, HJ Okano… - Molecular brain, 2013 - Springer
Background A long non-coding RNA (lncRNA), nuclear-enriched abundant transcript 1_2 (NEAT1_2),
constitutes nuclear bodies known as “paraspeckles”. Mutations of RNA binding …
constitutes nuclear bodies known as “paraspeckles”. Mutations of RNA binding …
The RNA-binding protein HuD regulates neuronal cell identity and maturation
…, S Shibata, Y Hayakawa, HJ Okano… - Proceedings of the …, 2005 - National Acad Sciences
Neural Hu proteins (HuB/C/D) are RNA-binding proteins that have been shown to induce
neuronal differentiation activity when overexpressed in immature neural progenitor cells or …
neuronal differentiation activity when overexpressed in immature neural progenitor cells or …
In vivo imaging of engrafted neural stem cells: its application in evaluating the optimal timing of transplantation for spinal cord injury
Neural stem/progenitor cells (NSPCs) hold promise in neural tissue replacement therapy
after spinal cord injury. However, understanding the survival time of grafted NSPCs and …
after spinal cord injury. However, understanding the survival time of grafted NSPCs and …
Noninvasive and real-time assessment of reconstructed functional human endometrium in NOD/SCID/γcnull immunodeficient mice
…, M Ono, H Miyoshi, HJ Okano… - Proceedings of the …, 2007 - National Acad Sciences
Human uterine endometrium exhibits unique properties of cyclical regeneration and
remodeling throughout reproductive life and also is subject to endometriosis through ectopic …
remodeling throughout reproductive life and also is subject to endometriosis through ectopic …
Epigenetic transcriptional activation of monocyte chemotactic protein 3 contributes to long-lasting neuropathic pain
…, K Omi, M Nakamura, H James Okano, H Okano… - Brain, 2013 - academic.oup.com
A multiplex analysis for profiling the expression of candidate genes along with epigenetic
modification may lead to a better understanding of the complex machinery of neuropathic pain. …
modification may lead to a better understanding of the complex machinery of neuropathic pain. …
Blockade of interleukin-6 signaling suppressed cochlear inflammatory response and improved hearing impairment in noise-damaged mice cochlea
Hearing impairment can be the cause of serious socio-economic disadvantages. Recent
studies have shown inflammatory responses in the inner ear co-occur with various damaging …
studies have shown inflammatory responses in the inner ear co-occur with various damaging …
Proliferation of neural and neuronal progenitors after global brain ischemia in young adult macaque monkeys
…, T Yamashima, L Zhao, HJ Okano, H Okano - Molecular and Cellular …, 2003 - Elsevier
To investigate the effect of global cerebral ischemia on brain cell proliferation in young adult
macaques, we infused 5-bromo-2′-deoxyuridine (BrdU), a DNA replication indicator, into …
macaques, we infused 5-bromo-2′-deoxyuridine (BrdU), a DNA replication indicator, into …