Adipocytes secrete a variety of bioactive molecules that affect the insulin sensitivity of other
tissues. We now show that the abundance of monocyte chemoattractant protein–1 (MCP-1) …

Endogenous retroviruses (ERVs), retrovirus-like elements with long terminal repeats, are
widely dispersed in the euchromatic compartment in mammalian cells, comprising ∼10% of …

The basic helix-loop-helix transcription factors Ascl1/Mash1, Hes1, and Olig2 regulate fate
choice of neurons, astrocytes, and oligodendrocytes, respectively. These same factors are …

Developmental gene expression is defined through cross-talk between the function of
transcription factors and epigenetic status, including histone modification. Although several …

Proper timing of gene expression is essential for many biological events, but the molecular
mechanisms that control timing remain largely unclear. It has been suggested that introns …

IL-15 is a cytokine critical for development, maintenance, and response of T cells, natural
killer (NK) cells, NK T cells, and dendritic cells. However, the identity and distribution of IL-15–…

IL-7 is a cytokine crucial for development and maintenance of lymphocytes and other
hematopoietic cells. However, how IL-7–expressing cells are distributed in lymphoid organs is not …

The olfactory bulb (OB) is one of the two major loci in the mammalian brain where newborn
neurons are constantly integrated into the neural circuit during postnatal life. Newborn …

Glucocorticoids are steroid hormones with strong anti-inflammatory and immunosuppressive
effects that are produced in a diurnal fashion. Although glucocorticoids have the potential to …

Notch signaling regulates tissue morphogenesis through cell–cell interactions. The Notch
effectors Hes1 and Hes7 are expressed in an oscillatory manner and regulate developmental …