In the 12 years since the publication of the first Consensus Paper of the WFSBP on biomarkers
of neurodegenerative dementias, enormous advancement has taken place in the field, …

Introduction Identifying circulating metabolites that are associated with cognition and dementia
may improve our understanding of the pathogenesis of dementia and provide crucial …

A sequence space model which describes the interplay of mutation and selection in molecular
evolution is shown to be equivalent to an Ising quantum chain. Three explicit examples …

Despite extensive efforts, half of patients with rare movement disorders such as hereditary
spastic paraplegias and cerebellar ataxias remain genetically unexplained, implicating novel …

Background Late-onset Alzheimer’s disease (AD) is a complex multifactorial affliction, the
pathogenesis of which is thought to involve gene-environment interactions that might be …

We analyze the equilibrium behavior of deterministic haploid mutation–selection models. To
this end, both the forward and the time-reversed evolution processes are considered. The …

We reconsider deterministic models of mutation and selection acting on populations of
sequences, or, equivalently, multilocus systems with complete linkage. Exact analytical results …

Small organic sensor molecules were prepared that bind and signal the presence of unlabeled
tripeptides in a sequence-selective manner. Sequence-selective peptide binding is a …

This article presents a fast and accurate method to measure human faces for medical
applications. To encode an object point, several random patterns are projected. A correlation …

Recently, Cruchaga et al. described the association of rare variants in the phospholipase
D3 gene (PLD3) with the risk of developing Alzheimer’s disease1; this observation resulted …