We report the sequencing and assembly of a reference genome for the human GM12878
Utah/Ceph cell line using the MinION (Oxford Nanopore Technologies) nanopore sequencer. …

The gold standard for clinical diagnosis of bacterial lower respiratory infections (LRIs) is
culture, which has poor sensitivity and is too slow to guide early, targeted antimicrobial therapy. …

Rationale: Bronchiectasis is classically considered a neutrophilic disorder, but eosinophilic
subtypes have recently been described. Objectives: To use multiple datasets available …

Bronchiectasis is increasing in prevalence worldwide, yet current treatments available are
limited to those alleviating symptoms and reducing exacerbations. The pathogenesis of the …

Background Culture-based microbiological investigation of hospital-acquired or ventilator-associated
pneumonia (HAP or VAP) is insensitive, with aetiological agents often unidentified. …

Background Riverine ecosystems are biogeochemical powerhouses driven largely by
microbial communities that inhabit water columns and sediments. Because rivers are used …

Rationale: Although inflammation and infection are key disease drivers in bronchiectasis,
few studies have integrated host inflammatory and microbiome data to guide precision …

Background Neutrophil serine proteases are involved in the pathogenesis of COVID-19 and
increased serine protease activity has been reported in severe and fatal infection. We …

Mycobacterium avium subspecies paratuberculosis (Map) causes Johne’s disease in animals
and is significantly associated with Crohn’s disease (CD) in humans. Our previous studies …

Lower respiratory infections (LRIs) accounted for three million deaths worldwide in 2016, the
leading infectious cause of mortality. The “gold standard” for investigation of bacterial LRIs …