User profiles for Holly A. R. Giles

Holly AR Giles

PhD Student, EMBL Heidelberg
Verified email at embl.de
Cited by 153

Multi-omics reveals clinically relevant proliferative drive associated with mTOR-MYC-OXPHOS activity in chronic lymphocytic leukemia

…, F Meier-Abt, S Scheinost, PM Bruch, HAR Giles… - Nature cancer, 2021 - nature.com
Chronic lymphocytic leukemia (CLL) has a complex pattern of driver mutations and much of
its clinical diversity remains unexplained. We devised a method for simultaneous subgroup …

Drug‐microenvironment perturbations reveal resistance mechanisms and prognostic subgroups in CLL

PM Bruch, HAR Giles, C Kolb, SA Herbst… - Molecular Systems …, 2022 - embopress.org
The tumour microenvironment and genetic alterations collectively influence drug efficacy in
cancer, but current evidence is limited and systematic analyses are lacking. Using chronic …

Combinatorial drug-microenvironment interaction mapping reveals cell-extrinsic drug resistance mechanisms and clinically relevant patient subgroups in CLL

PM Bruch, HAR Giles, C Kolb, SA Herbst, T Becirovic… - bioRxiv, 2021 - biorxiv.org
The tumour microenvironment and genetic alterations collectively influence drug efficacy in
cancer, but current evidence is limited to small scale studies and systematic analyses are …

Genome-wide association study identifies multiple risk loci for chronic lymphocytic leukemia

…, GJ Weiner, L Conde, PM Bracci, J Riby, EA Holly… - Nature …, 2013 - nature.com
Genome-wide association studies (GWAS) have previously identified 13 loci associated
with risk of chronic lymphocytic leukemia or small lymphocytic lymphoma (CLL). To identify …

Genome-wide association study identifies multiple susceptibility loci for diffuse large B cell lymphoma

…, MP Purdue, CM Vajdic, JJ Spinelli, GG Giles… - Nature …, 2014 - nature.com
Diffuse large B cell lymphoma (DLBCL) is the most common lymphoma subtype and is
clinically aggressive. To identify genetic susceptibility loci for DLBCL, we conducted a meta-…

[HTML][HTML] Meta-analysis of genome-wide association studies discovers multiple loci for chronic lymphocytic leukemia

…, CM Vajdic, P Cocco, Y Zhang, GG Giles… - Nature …, 2016 - nature.com
Chronic lymphocytic leukemia (CLL) is a common lymphoid malignancy with strong
heritability. To further understand the genetic susceptibility for CLL and identify common loci …

[PDF][PDF] Genome-wide association study identifies five susceptibility loci for follicular lymphoma outside the HLA region

…, H Ghesquières, BK Link, LM Morton, EA Holly… - The American Journal of …, 2014 - cell.com
Genome-wide association studies (GWASs) of follicular lymphoma (FL) have previously
identified human leukocyte antigen (HLA) gene variants. To identify additional FL susceptibility …

[HTML][HTML] Genome-wide association analysis implicates dysregulation of immunity genes in chronic lymphocytic leukaemia

…, P Cocco, H Marr, Y Zhang, T Zheng, GG Giles… - Nature …, 2017 - nature.com
Several chronic lymphocytic leukaemia (CLL) susceptibility loci have been reported; however,
much of the heritable risk remains unidentified. Here we perform a meta-analysis of six …

[PDF][PDF] Quantification of differential transcription factor activity and multiomics-based classification into activators and repressors: diffTF

…, A Reyes-Palomares, G Palla, KD Rasmussen, H Giles… - Cell reports, 2019 - cell.com
Transcription factors (TFs) regulate many cellular processes and can therefore serve as
readouts of the signaling and regulatory state. Yet for many TFs, the mode of action—repressing …

[HTML][HTML] A genome-wide association study of marginal zone lymphoma shows association to the HLA region

…, J Turner, Y Zhang, MP Purdue, GG Giles… - Nature …, 2015 - nature.com
Marginal zone lymphoma (MZL) is the third most common subtype of B-cell non-Hodgkin
lymphoma. Here we perform a two-stage GWAS of 1,281 MZL cases and 7,127 controls of …