User profiles for Holly A. R. Giles
Holly AR GilesPhD Student, EMBL Heidelberg Verified email at embl.de Cited by 153 |
Multi-omics reveals clinically relevant proliferative drive associated with mTOR-MYC-OXPHOS activity in chronic lymphocytic leukemia
Chronic lymphocytic leukemia (CLL) has a complex pattern of driver mutations and much of
its clinical diversity remains unexplained. We devised a method for simultaneous subgroup …
its clinical diversity remains unexplained. We devised a method for simultaneous subgroup …
Drug‐microenvironment perturbations reveal resistance mechanisms and prognostic subgroups in CLL
The tumour microenvironment and genetic alterations collectively influence drug efficacy in
cancer, but current evidence is limited and systematic analyses are lacking. Using chronic …
cancer, but current evidence is limited and systematic analyses are lacking. Using chronic …
Combinatorial drug-microenvironment interaction mapping reveals cell-extrinsic drug resistance mechanisms and clinically relevant patient subgroups in CLL
PM Bruch, HAR Giles, C Kolb, SA Herbst, T Becirovic… - bioRxiv, 2021 - biorxiv.org
The tumour microenvironment and genetic alterations collectively influence drug efficacy in
cancer, but current evidence is limited to small scale studies and systematic analyses are …
cancer, but current evidence is limited to small scale studies and systematic analyses are …
Genome-wide association study identifies multiple risk loci for chronic lymphocytic leukemia
Genome-wide association studies (GWAS) have previously identified 13 loci associated
with risk of chronic lymphocytic leukemia or small lymphocytic lymphoma (CLL). To identify …
with risk of chronic lymphocytic leukemia or small lymphocytic lymphoma (CLL). To identify …
Genome-wide association study identifies multiple susceptibility loci for diffuse large B cell lymphoma
Diffuse large B cell lymphoma (DLBCL) is the most common lymphoma subtype and is
clinically aggressive. To identify genetic susceptibility loci for DLBCL, we conducted a meta-…
clinically aggressive. To identify genetic susceptibility loci for DLBCL, we conducted a meta-…
[HTML][HTML] Meta-analysis of genome-wide association studies discovers multiple loci for chronic lymphocytic leukemia
Chronic lymphocytic leukemia (CLL) is a common lymphoid malignancy with strong
heritability. To further understand the genetic susceptibility for CLL and identify common loci …
heritability. To further understand the genetic susceptibility for CLL and identify common loci …
[PDF][PDF] Genome-wide association study identifies five susceptibility loci for follicular lymphoma outside the HLA region
…, H Ghesquières, BK Link, LM Morton, EA Holly… - The American Journal of …, 2014 - cell.com
Genome-wide association studies (GWASs) of follicular lymphoma (FL) have previously
identified human leukocyte antigen (HLA) gene variants. To identify additional FL susceptibility …
identified human leukocyte antigen (HLA) gene variants. To identify additional FL susceptibility …
[HTML][HTML] Genome-wide association analysis implicates dysregulation of immunity genes in chronic lymphocytic leukaemia
Several chronic lymphocytic leukaemia (CLL) susceptibility loci have been reported; however,
much of the heritable risk remains unidentified. Here we perform a meta-analysis of six …
much of the heritable risk remains unidentified. Here we perform a meta-analysis of six …
[PDF][PDF] Quantification of differential transcription factor activity and multiomics-based classification into activators and repressors: diffTF
Transcription factors (TFs) regulate many cellular processes and can therefore serve as
readouts of the signaling and regulatory state. Yet for many TFs, the mode of action—repressing …
readouts of the signaling and regulatory state. Yet for many TFs, the mode of action—repressing …
[HTML][HTML] A genome-wide association study of marginal zone lymphoma shows association to the HLA region
Marginal zone lymphoma (MZL) is the third most common subtype of B-cell non-Hodgkin
lymphoma. Here we perform a two-stage GWAS of 1,281 MZL cases and 7,127 controls of …
lymphoma. Here we perform a two-stage GWAS of 1,281 MZL cases and 7,127 controls of …