The regenerative capacity of the injured CNS in adult mammals is severely limited, yet axons
in the peripheral nervous system (PNS) regrow, albeit to a limited extent, after injury. We …

Neurons differ in their responses to injury, but the underlying mechanisms remain poorly
understood. Using quantitative proteomics, we characterized the injury-triggered response from …

Chemorepulsion by semaphorins plays a critical role during the development of neuronal
projections. Although semaphorin-induced chemoattraction has been reported in vitro, the …

Commissural axon guidance requires complex modulations of growth cone sensitivity to
midline-derived cues, but underlying mechanisms in vertebrates remain largely unknown. By …

The chemotropic guidance cue netrin-1 promotes neurite outgrowth through its receptor
Deleted in Colorectal Cancer (DCC) via activation of Rac1. The guanine nucleotide exchange …

Axonal receptors for class 3 semaphorins (Sema3s) are heterocomplexes of neuropilins (Nrps)
and Plexin‐As signalling coreceptors. In the developing cerebral cortex, the Ig …

Robo-Slit and Plexin-Semaphorin signaling participate in various developmental and pathogenic
processes. During commissural axon guidance in the spinal cord, chemorepulsion by …

After axotomy, neuronal survival and growth cone re-formation are required for axon regeneration.
We discovered that doublecortin-like kinases (DCLKs), members of the doublecortin (…

Retinal ganglion cells (RGCs) drive diverse, light-evoked behaviors that range from conscious
visual perception to subconscious, non–image-forming behaviors. It is thought that RGCs …

The Neurotrophic factor gdnf plays diverse developmental roles, supporting survival and
also acting as a chemoattractant for axon and cell migration. We report that in the developing …