The Tabula Sapiens: A multiple-organ, single-cell transcriptomic atlas of humans

…, J Xie, AR Yung, Y Zhang, AM Detweiler, H Mekonen… - Science, 2022 - science.org
Molecular characterization of cell types using single-cell transcriptome sequencing is
revolutionizing cell biology and enabling new insights into the physiology of human organs. We …

[HTML][HTML] Early prediction of preeclampsia in pregnancy with cell-free RNA

…, RV Sit, M Tan, AM Detweiler, H Mekonen… - Nature, 2022 - nature.com
Liquid biopsies that measure circulating cell-free RNA (cfRNA) offer an opportunity to study
the development of pregnancy-related complications in a non-invasive manner and to bridge …

A sandbox for prediction and integration of DNA, RNA, and proteins in single cells

…, H Lickert, A McGeever, H Mekonen… - Thirty-fifth conference …, 2021 - openreview.net
The last decade has witnessed a technological arms race to encode the molecular states of
cells into DNA libraries, turning DNA sequencers into scalable single-cell microscopes. …

Zebrahub–multimodal zebrafish developmental atlas reveals the state-transition dynamics of late-vertebrate pluripotent axial progenitors

…, X Zhao, Y Liu, AM Detweiler, S Paul, H Mekonen… - bioRxiv, 2023 - biorxiv.org
Elucidating the developmental processes of organisms requires a comprehensive understanding
of cellular lineages in the spatial, temporal, and molecular domains. In this study, we …

[HTML][HTML] Generation of an isoform-level transcriptome atlas of macrophage activation

AC Vollmers, HE Mekonen, S Campos… - Journal of Biological …, 2021 - ASBMB
RNA-seq is routinely used to measure gene expression changes in response to cell perturbation.
Genes upregulated or downregulated following some perturbation are designated as …

[PDF][PDF] Evaluation of transitional and modern hives for honey production in the Mid Rift Valley of Ethiopia

…, CG Abi D, M Mekonen Wolda Tsadik… - Bulletin of Animal …, 2016 - repository.au-ibar.org
… The overall average annual honey yield performance clearly revealed that both modern
bee … practices can improve honey yield and ensure better quality of honey compared to …

[HTML][HTML] R2C2+ UMI: Combining concatemeric consensus sequencing with unique molecular identifiers enables ultra-accurate sequencing of amplicons on Oxford …

…, J Verhage, C Neudorf, R Corbett-Detig, H Mekonen… - bioRxiv, 2023 - ncbi.nlm.nih.gov
The sequencing of PCR amplicons is a core application of high-throughput sequencing
technology. Using unique molecular identifiers (UMIs), individual amplified molecules can be …

[HTML][HTML] In host evolution of beta lactam resistance during active treatment for Pseudomonas aeruginosa bacteremia

…, AM Detweiler, H Mekonen… - Frontiers in Cellular …, 2023 - ncbi.nlm.nih.gov
Multidrug-resistant (MDR) Pseudomonas aeruginosa has been declared a serious threat by
the United States Centers for Disease Control and Prevention. Here, we used whole …

[PDF][PDF] Characterization of Honey Production and Marketing Systems: Constraints and Opportunities in Ada Berga District, West Shoa Zone, Oromia, Ethiopia

E Mekonnen - 2016 - cgspace.cgiar.org
… few decades couldn’t improve hive productivity and honey production so far. This, we believe,
is because of the various honey production constraints with varied consequences. Thus, …

[PDF][PDF] The Challenges and Opportunities of Honey Production Systems in Ada Berga District, West Shoa Zone, Oromia, Ethiopia

E Mekonnen, A Jenberie, Y Mekuriaw… - Food Science and Quality …, 2018 - core.ac.uk
honey producer in Africa and tenth largest honey producer in the world. Unlike many other
commodities such as crop and livestock, honey … The same to that, honey production is also …