User profiles for Hong-Ru Chen

Hong-Ru Chen

- Verified email at besson-girard.fr - Cited by 571

Hong-Ru Chen

- Verified email at virginia.edu - Cited by 515

[HTML][HTML] Dengue virus non-structural protein 1: a pathogenic factor, therapeutic target, and vaccine candidate

HR Chen, YC Lai, TM Yeh - Journal of biomedical science, 2018 - Springer
Dengue virus (DENV) infection is the most common mosquito-transmitted viral infection.
DENV infection can cause mild dengue fever or severe dengue hemorrhagic fever (DHF)/…

[HTML][HTML] Capillary-associated microglia regulate vascular structure and function through PANX1-P2RY12 coupling in mice

…, K Sharma, DH Lentferink, YY Sun, HR Chen… - Nature …, 2021 - nature.com
Microglia are brain-resident immune cells with a repertoire of functions in the brain. However,
the extent of their interactions with the vasculature and potential regulation of vascular …

[HTML][HTML] Re-evaluation of the pathogenic roles of nonstructural protein 1 and its antibodies during dengue virus infection

YC Chuang, SY Wang, YS Lin, HR Chen… - Journal of biomedical …, 2013 - Springer
Dengue virus (DENV) infection can cause life-threatening dengue hemorrhagic fever (DHF)
and dengue shock syndrome (DSS). Vascular leakage and abnormal hemorrhage are the …

Cadmium tolerance of carbon assimilation enzymes and chloroplast in Zn/Cd hyperaccumulator Picris divaricata

…, RL Qiu, YT Tang, PJ Hu, H Qiu, HR Chen… - Journal of plant …, 2010 - Elsevier
To better understand the photosynthesis under stress, the effect of cadmium on carbon
assimilation and chloroplast ultrastructure of a newly found Zn/Cd hyperaccumulator Picris …

[HTML][HTML] Dengue virus nonstructural protein 1 induces vascular leakage through macrophage migration inhibitory factor and autophagy

HR Chen, YC Chuang, YS Lin, HS Liu… - PLoS neglected …, 2016 - journals.plos.org
Dengue virus (DENV) is the most common mosquito-borne flavivirus; it can either cause
mild dengue fever or the more severe dengue hemorrhagic fever (DHF) and dengue shock …

[HTML][HTML] Pathogenic roles of macrophage migration inhibitory factor during dengue virus infection

YC Chuang, HR Chen, TM Yeh - Mediators of inflammation, 2015 - hindawi.com
Dengue virus (DENV) infection is the most common cause of viral hemorrhagic fever, which
can lead to life-threatening dengue hemorrhagic fever/dengue shock syndrome (DHF/DSS). …

[HTML][HTML] Macrophage migration inhibitory factor is critical for dengue NS1-induced endothelial glycocalyx degradation and hyperpermeability

HR Chen, CH Chao, CC Liu, TS Ho, HP Tsai… - PLoS …, 2018 - journals.plos.org
Vascular leakage is one of the salient characteristics of severe dengue. Nonstructural protein
1 (NS1) of dengue virus (DENV) can stimulate endothelial cells to secrete endothelial …

Fate mapping via CCR2-CreER mice reveals monocyte-to-microglia transition in development and neonatal stroke

HR Chen, YY Sun, CW Chen, YM Kuo, IS Kuan… - Science …, 2020 - science.org
Whether monocytes contribute to the brain microglial pool in development or after brain
injury remains contentious. To address this issue, we generated CCR2-CreER mice to track …

[HTML][HTML] Monocytes promote acute neuroinflammation and become pathological microglia in neonatal hypoxic-ischemic brain injury

HR Chen, CW Chen, YM Kuo, B Chen, IS Kuan… - Theranostics, 2022 - ncbi.nlm.nih.gov
Rationale: Monocytes belong to the mononuclear phagocyte system and are immune
responders to tissue injury and infection. There were also reports of monocytes transforming to …

Exposure-based assessment of chemical teratogenicity using morphogenetic aggregates of human embryonic stem cells

Y Marikawa, HR Chen, M Menor, Y Deng… - Reproductive …, 2020 - Elsevier
Pluripotent stem cells recapitulate many aspects of embryogenesis in vitro. Here, we
established a novel culture system to differentiate human embryonic stem cell aggregates (HESCA)…