Stroke is one of the leading causes of mortality and disability worldwide. Uncovering the
cellular and molecular pathophysiological processes in stroke have been a top priority. Long …

Cardiac arrest victims may experience transient brain hypoperfusion leading to delayed death
of hippocampal CA1 neurons and cognitive impairment. We prevented this in adult rats by …

ATP-sensitive potassium (K ATP) channels are weak, inward rectifiers that couple metabolic
status to cell membrane electrical activity, thus modulating many cellular functions. An …

Alzheimer's disease (AD) is a neurodegenerative disorder associated with continual decline
in cognition and ability to perform routine functions such as remembering familiar places or …

In neuronal synapses, PDZ domains [postsynaptic density-95 (PSD-95)/Discs large/zona
occludens-1] of PSD-95 proteins interact with C termini of NMDA receptor [NMDAR (NR)] …

Background and Purpose— Postsynaptic density-95 inhibitors reduce ischemic brain damage
without inhibiting excitatory neurotransmission, circumventing the negative consequences …

Accumulated evidence suggests that bone marrow stromal cells (BMSCs) are capable of
regenerating damaged tissue. This study evaluated whether intravenously (noninvasively) …

TRPM2 is a Ca 2+ ‐permeable member of the transient receptor potential melastatin family
of cation channels whose activation by reactive oxygen/nitrogen species (ROS/RNS) and …

Glioblastomas are progressive brain tumors with devastating proliferative and invasive
characteristics. Ion channels are the second largest target class for drug development. In this …

Background Our previous study found that suppression of TRPM7 reduced neuronal death
in adult rat ischemic brain injury. It was reported that carvacrol blocked TRPM7 and …