[PDF][PDF] The global burden of liver disease: the major impact of China

FS Wang, JG Fan, Z Zhang, B Gao, HY Wang - Hepatology, 2014 - Wiley Online Library
Liver disease is a major cause of illness and death worldwide. In China alone, liver diseases,
primarily viral hepatitis (predominantly hepatitis B virus [HBV]), nonalcoholic fatty liver …

[HTML][HTML] New knowledge of the mechanisms of sorafenib resistance in liver cancer

YJ Zhu, B Zheng, HY Wang, L Chen - Acta Pharmacologica Sinica, 2017 - nature.com
Sorafenib is an oral multikinase inhibitor that suppresses tumor cell proliferation and
angiogenesis and promotes tumor cell apoptosis. It was approved by the FDA for the treatment of …

[HTML][HTML] Role of nonresolving inflammation in hepatocellular carcinoma development and progression

LX Yu, Y Ling, HY Wang - NPJ precision oncology, 2018 - nature.com
Hepatocellular carcinoma (HCC) has become a leading cause of cancer-related death,
making the elucidation of its underlying mechanisms an urgent priority. Inflammation is an …

EpCAM-positive hepatocellular carcinoma cells are tumor-initiating cells with stem/progenitor cell features

…, J Ji, A Budhu, M Forgues, W Yang, HY Wang… - Gastroenterology, 2009 - Elsevier
BACKGROUND & AIMS: Cancer progression/metastases and embryonic development share
many properties including cellular plasticity, dynamic cell motility, and integral interaction …

[PDF][PDF] Exosome-transmitted lncARSR promotes sunitinib resistance in renal cancer by acting as a competing endogenous RNA

…, Y Gao, W Chen, F Liu, W Sun, XF Li, X Wang, Y Wang… - Cancer cell, 2016 - cell.com
Sunitinib resistance is a major challenge for advanced renal cell carcinoma (RCC).
Understanding the underlying mechanisms and developing effective strategies against sunitinib …

[PDF][PDF] Identification of microRNA‐181 by genome‐wide screening as a critical player in EpCAM–positive hepatic cancer stem cells

…, HY Wang, ZY Tang, CM Croce, XW Wang - …, 2009 - Wiley Online Library
MicroRNAs (miRNAs) are endogenous small noncoding RNAs that regulate gene expression
with functional links to tumorigenesis. Hepatocellular carcinoma (HCC) is the most …

[PDF][PDF] TGF-β-miR-34a-CCL22 signaling-induced Treg cell recruitment promotes venous metastases of HBV-positive hepatocellular carcinoma

…, Y Yuan, HY Wang, SQ Cheng, D Xie, XF Wang - Cancer cell, 2012 - cell.com
Portal vein tumor thrombus (PVTT) is strongly correlated to a poor prognosis for patients
with hepatocellular carcinoma (HCC). In this study, we uncovered a causative link between …

Wnt/β-catenin signaling contributes to activation of normal and tumorigenic liver progenitor cells

…, L Tang, XN Kong, C Chen, SQ Liu, MC Wu, HY Wang - Cancer research, 2008 - AACR
Adult hepatic progenitor (oval) cells are facultative stem cells in liver, which participate in a
range of human liver diseases, including hepatocellular carcinoma (HCC). However, the …

Transcutaneous vagus nerve stimulation modulates default mode network in major depressive disorder

…, J Liu, H Wang, G Zhang, X Chen, S Shi, L Wang… - Biological …, 2016 - Elsevier
Background Depression is the most common form of mental disorder in community and
health care settings and current treatments are far from satisfactory. Vagus nerve stimulation (…

Endotoxin accumulation prevents carcinogen‐induced apoptosis and promotes liver tumorigenesis in rodents

…, C Wang, HL Zhang, GW Cao, MC Wu, HY Wang - …, 2010 - Wiley Online Library
Increasing evidence suggests that the presence of endotoxemia is of substantial clinical
relevance to patients with cirrhosis, but it is unclear whether and how gut‐derived LPS amplifies …