User profiles for Hongbo Zhang

Hongbo Zhang

- Verified email at abo.fi - Cited by 10656

Hongbo Zhang

- Verified email at chd.edu.cn - Cited by 2165

NAD+ repletion improves mitochondrial and stem cell function and enhances life span in mice

H Zhang, D Ryu, Y Wu, K Gariani, X Wang, P Luan… - Science, 2016 - science.org
Adult stem cells (SCs) are essential for tissue maintenance and regeneration yet are
susceptible to senescence during aging. We demonstrate the importance of the amount of the …

[HTML][HTML] Cells of the adult human heart

…, K Saeb-Parsy, G Patone, JJ Boyle, H Zhang, H Zhang… - Nature, 2020 - nature.com
Cardiovascular disease is the leading cause of death worldwide. Advanced insights into
disease mechanisms and therapeutic strategies require a deeper understanding of the …

Synergistic effects from graphene and carbon nanotubes enable flexible and robust electrodes for high-performance supercapacitors

Y Cheng, S Lu, H Zhang, CV Varanasi, J Liu - Nano letters, 2012 - ACS Publications
Flexible and lightweight energy storage systems have received tremendous interest recently
due to their potential applications in wearable electronics, roll-up displays, and other …

Hypoxia‐inducible factor‐1α contributes to hypoxia‐induced chemoresistance in gastric cancer

L Liu, X Ning, L Sun, H Zhang, Y Shi, C Guo… - Cancer …, 2008 - Wiley Online Library
Hypoxia induced drug resistance is a major obstacle in the development of effective cancer
therapy. Our previous study revealed that hypoxia‐inducible factor‐1 (HIF‐1), the major …

Engineered extracellular vesicles for cancer therapy

X Zhang, H Zhang, J Gu, J Zhang, H Shi… - Advanced …, 2021 - Wiley Online Library
Extracellular vesicles (EVs) have emerged as a novel cell‐free strategy for the treatment of
many diseases including cancer. As a result of their natural properties to mediate cell‐to‐cell …

Integrated multi-objective stochastic fuzzy programming and AHP method for agricultural water and land optimization allocation under multiple uncertainties

C Ren, Z Li, H Zhang - Journal of cleaner production, 2019 - Elsevier
Optimization allocation of agricultural water and land is a very complex system involves multiple
objectives. Moreover, weights of each objective were signed by subjective judgement of …

Engineered neutrophil-derived exosome-like vesicles for targeted cancer therapy

J Zhang, C Ji, H Zhang, H Shi, F Mao, H Qian, W Xu… - Science …, 2022 - science.org
Neutrophils are the most abundant innate immune cells in human circulation; however, their
derived exosomes have been rarely studied for tumor treatment. Here, we reported that …

[HTML][HTML] Tumor exosome-based nanoparticles are efficient drug carriers for chemotherapy

T Yong, X Zhang, N Bie, H Zhang, X Zhang, F Li… - Nature …, 2019 - nature.com
Developing biomimetic nanoparticles without loss of the integrity of proteins remains a
major challenge in cancer chemotherapy. Here, we develop a biocompatible tumor-cell-…

Enhancing mitochondrial proteostasis reduces amyloid-β proteotoxicity

…, M Romani, L Mouchiroud, JS Beck, H Zhang… - Nature, 2017 - nature.com
Alzheimer’s disease is a common and devastating disease characterized by aggregation of
the amyloid-β peptide. However, we know relatively little about the underlying molecular …

[HTML][HTML] Pharmaceutical electrospinning and 3D printing scaffold design for bone regeneration

Z Wang, Y Wang, J Yan, K Zhang, F Lin, L Xiang… - Advanced drug delivery …, 2021 - Elsevier
Bone regenerative engineering provides a great platform for bone tissue regeneration
covering cells, growth factors and other dynamic forces for fabricating scaffolds. Diversified …