NAD+ repletion improves mitochondrial and stem cell function and enhances life span in mice
Adult stem cells (SCs) are essential for tissue maintenance and regeneration yet are
susceptible to senescence during aging. We demonstrate the importance of the amount of the …
susceptible to senescence during aging. We demonstrate the importance of the amount of the …
[HTML][HTML] Cells of the adult human heart
…, K Saeb-Parsy, G Patone, JJ Boyle, H Zhang, H Zhang… - Nature, 2020 - nature.com
Cardiovascular disease is the leading cause of death worldwide. Advanced insights into
disease mechanisms and therapeutic strategies require a deeper understanding of the …
disease mechanisms and therapeutic strategies require a deeper understanding of the …
Synergistic effects from graphene and carbon nanotubes enable flexible and robust electrodes for high-performance supercapacitors
Flexible and lightweight energy storage systems have received tremendous interest recently
due to their potential applications in wearable electronics, roll-up displays, and other …
due to their potential applications in wearable electronics, roll-up displays, and other …
Hypoxia‐inducible factor‐1α contributes to hypoxia‐induced chemoresistance in gastric cancer
L Liu, X Ning, L Sun, H Zhang, Y Shi, C Guo… - Cancer …, 2008 - Wiley Online Library
Hypoxia induced drug resistance is a major obstacle in the development of effective cancer
therapy. Our previous study revealed that hypoxia‐inducible factor‐1 (HIF‐1), the major …
therapy. Our previous study revealed that hypoxia‐inducible factor‐1 (HIF‐1), the major …
Engineered extracellular vesicles for cancer therapy
X Zhang, H Zhang, J Gu, J Zhang, H Shi… - Advanced …, 2021 - Wiley Online Library
Extracellular vesicles (EVs) have emerged as a novel cell‐free strategy for the treatment of
many diseases including cancer. As a result of their natural properties to mediate cell‐to‐cell …
many diseases including cancer. As a result of their natural properties to mediate cell‐to‐cell …
Integrated multi-objective stochastic fuzzy programming and AHP method for agricultural water and land optimization allocation under multiple uncertainties
C Ren, Z Li, H Zhang - Journal of cleaner production, 2019 - Elsevier
Optimization allocation of agricultural water and land is a very complex system involves multiple
objectives. Moreover, weights of each objective were signed by subjective judgement of …
objectives. Moreover, weights of each objective were signed by subjective judgement of …
Engineered neutrophil-derived exosome-like vesicles for targeted cancer therapy
Neutrophils are the most abundant innate immune cells in human circulation; however, their
derived exosomes have been rarely studied for tumor treatment. Here, we reported that …
derived exosomes have been rarely studied for tumor treatment. Here, we reported that …
[HTML][HTML] Tumor exosome-based nanoparticles are efficient drug carriers for chemotherapy
T Yong, X Zhang, N Bie, H Zhang, X Zhang, F Li… - Nature …, 2019 - nature.com
Developing biomimetic nanoparticles without loss of the integrity of proteins remains a
major challenge in cancer chemotherapy. Here, we develop a biocompatible tumor-cell-…
major challenge in cancer chemotherapy. Here, we develop a biocompatible tumor-cell-…
Enhancing mitochondrial proteostasis reduces amyloid-β proteotoxicity
…, M Romani, L Mouchiroud, JS Beck, H Zhang… - Nature, 2017 - nature.com
Alzheimer’s disease is a common and devastating disease characterized by aggregation of
the amyloid-β peptide. However, we know relatively little about the underlying molecular …
the amyloid-β peptide. However, we know relatively little about the underlying molecular …
[HTML][HTML] Pharmaceutical electrospinning and 3D printing scaffold design for bone regeneration
Z Wang, Y Wang, J Yan, K Zhang, F Lin, L Xiang… - Advanced drug delivery …, 2021 - Elsevier
Bone regenerative engineering provides a great platform for bone tissue regeneration
covering cells, growth factors and other dynamic forces for fabricating scaffolds. Diversified …
covering cells, growth factors and other dynamic forces for fabricating scaffolds. Diversified …