Background In late December, 2019, patients presenting with viral pneumonia due to an
unidentified microbial agent were reported in Wuhan, China. A novel coronavirus was …

The 1000 Genomes Project set out to provide a comprehensive description of common human
genetic variation by applying whole-genome sequencing to a diverse set of individuals …

Residents of the Tibetan Plateau show heritable adaptations to extreme altitude. We
sequenced 50 exomes of ethnic Tibetans, encompassing coding sequences of 92% of human …

Circulating in China and 158 other countries and areas, the ongoing COVID-19 outbreak has
caused devastating mortality and posed a great threat to public health. However, efforts to …

High-throughput sequencing technology enables population-level surveys of human genomic
variation. Here, we examine the joint allele frequency distributions across continental …

The genetic diversity of Yersinia pestis, the etiologic agent of plague, is extremely limited
because of its recent origin coupled with a slow clock rate. Here we identified 2,326 SNPs from …

DNA methylation plays an important role in biological processes in human health and
disease. Recent technological advances allow unbiased whole-genome DNA methylation (…

Targeted capture combined with massively parallel exome sequencing is a promising approach
to identify genetic variants implicated in human traits. We report exome sequencing of …

Here we integrate the de novo assembly of an Asian and an African genome with the NCBI
reference human genome, as a step toward constructing the human pan-genome. We …

Background and Aims Bacteremia is a common serious manifestation of disease in the
intensive care unit (ICU), which requires quick and accurate determinations of pathogens to …