Crystal structure of the RNA-guided immune surveillance Cascade complex in Escherichia coli
H Zhao, G Sheng, J Wang, M Wang, G Bunkoczi… - Nature, 2014 - nature.com
Clustered regularly interspaced short palindromic repeats (CRISPR) together with CRISPR-associated
(Cas) proteins form the CRISPR/Cas system to defend against foreign nucleic …
(Cas) proteins form the CRISPR/Cas system to defend against foreign nucleic …
[PDF][PDF] The hemolysin A secretion system is a multi-engine pump containing three ABC transporters
Type 1 secretion systems (T1SSs) are widespread in pathogenic Gram-negative bacteria,
extruding protein substrates following synthesis of the entire polypeptide. The Escherichia coli …
extruding protein substrates following synthesis of the entire polypeptide. The Escherichia coli …
[PDF][PDF] Activation and closed-state inactivation mechanisms of the human voltage-gated KV4 channel complexes
The voltage-gated ion channel activity depends on both activation (transition from the resting
state to the open state) and inactivation. Inactivation is a self-restraint mechanism to limit …
state to the open state) and inactivation. Inactivation is a self-restraint mechanism to limit …
[HTML][HTML] Structural and mechanistic basis of PAM-dependent spacer acquisition in CRISPR-Cas systems
Bacteria acquire memory of viral invaders by incorporating invasive DNA sequence elements
into the host CRISPR locus, generating a new spacer within the CRISPR array. We report …
into the host CRISPR locus, generating a new spacer within the CRISPR array. We report …
Structure-based cleavage mechanism of Thermus thermophilus Argonaute DNA guide strand-mediated DNA target cleavage
G Sheng, H Zhao, J Wang, Y Rao… - Proceedings of the …, 2014 - National Acad Sciences
We report on crystal structures of ternary Thermus thermophilus Argonaute (TtAgo) complexes
with 5′-phosphorylated guide DNA and a series of DNA targets. These ternary complex …
with 5′-phosphorylated guide DNA and a series of DNA targets. These ternary complex …
Structural insights into the regulation of human serine palmitoyltransferase complexes
…, N Somashekarappa, G Han, H Zhao… - Nature Structural & …, 2021 - nature.com
Sphingolipids are essential lipids in eukaryotic membranes. In humans, the first and rate-limiting
step of sphingolipid synthesis is catalyzed by the serine palmitoyltransferase …
step of sphingolipid synthesis is catalyzed by the serine palmitoyltransferase …
[PDF][PDF] Autonomous generation and loading of DNA guides by bacterial Argonaute
…, Y Zhu, EM Timmers, Y Zhang, H Zhao… - Molecular cell, 2017 - cell.com
Several prokaryotic Argonaute proteins (pAgos) utilize small DNA guides to mediate host
defense by targeting invading DNA complementary to the DNA guide. It is unknown how these …
defense by targeting invading DNA complementary to the DNA guide. It is unknown how these …
Structural and functional insights into Spns2-mediated transport of sphingosine-1-phosphate
Sphingosine-1-phosphate (S1P) is an important signaling sphingolipid that regulates the
immune system, angiogenesis, auditory function, and epithelial and endothelial barrier integrity…
immune system, angiogenesis, auditory function, and epithelial and endothelial barrier integrity…
Multi-stimuli responsive organic polymorphic crystals: anisotropic elasticity and plasticity, mechanochromism and photomechanical motions
Z Jiang, H Zhao, W Wu, K Chen, H Yu… - Journal of Materials …, 2023 - pubs.rsc.org
The development of organic crystals responsive to multiple external stimuli (mechanical force,
light and heat) as potential smart materials is always compelling but challenging. Herein, …
light and heat) as potential smart materials is always compelling but challenging. Herein, …
Organic Crystals with Response to Multiple Stimuli: Mechanical Bending, Acid‐Induced Bending and Heating‐Induced Jumping
…, K Chen, X Zhang, T Wang, S Li, H Zhao… - … A European Journal, 2023 - Wiley Online Library
Multiple stimuli‐responsive molecular crystals are attracting extensive attentions due to their
potential as smart materials, such as molecular machines, actuators, and sensors. However, …
potential as smart materials, such as molecular machines, actuators, and sensors. However, …