The clinical applicability of porcine xenotransplantation—a long-investigated alternative to
the scarce availability of human organs for patients with organ failure—is limited by molecular …

Embryonic stem (ES) cells are powerful tools for generating genetically modified animals
that can assist in advancing our knowledge of mammalian physiology and disease. Pigs …

Multiple Ca 2+ channels confer diverse functions to hair cells of the auditory and vestibular
organs in the mammalian inner ear. We used gene-targeting technology to generate α 1D Ca …

Technology of somatic cell nuclear transfer (SCNT) has been adapted worldwide to generate
transgenic animals, although the traditional procedure relies largely on instrumental …

Production of transgenic animals via somatic cell nuclear transfer (SCNT) has been adapted
worldwide, but this application is somewhat limited by its relatively low efficiency. In this …

Data analysis in somatic cell nuclear transfer (SCNT) research is usually limited to several
hundreds or thousands of reconstructed embryos. Here, we report mass results obtained with …

Although drug-induced and age-related hearing losses are frequent otologic problems
affecting millions of people, their underlying mechanisms remain uncertain. The inner ear is …

The endolymph in the endolymphatic sac (ES) is acidic (pH 6.6–7). Maintaining this acidic
lumen is believed to be important for the normal function of the ES. The acid-base regulation …

Acid–base homeostasis of endolymph is thought to be essential for normal inner ear function.
This assumption was supported by clinical data from individuals affected by autosomal …

Prior studies have shown that kreisler mutants display early inner ear defects that are related
to abnormal hindbrain development and signaling. These defects in kreisler mice have …