Colorectal cancer (CRC) is among the most common malignancies with limited treatments
other than surgery. The tumor microenvironment (TME) profiling enables the discovery of …

Natural compounds are important sources of anticancer drugs. Rhizoma Bolbostemmatis (Chinese
name “Tu Bei Mu”) is the dry tuber of Bolbostemma paniculatum (Maxim.) Franquet (…

Saponins are natural glycosides of steroid or triterpene which exhibited many different
biological and pharmacological activities. Notably, saponins can also activate the mammalian …

The incidence and mortality rates of many non-reproductive human cancers are generally
higher in males than in females. However, the immunological mechanism underlying sexual …

CD8 + T cells are the key executioners of the adaptive immune arm, which mediates
antitumor and antiviral immunity. Naïve CD8 + T cells develop in the thymus and are quickly …

The polysaccharide from the roots of Actinidia eriantha (AEPS), a potent antitumor agent and
immunological adjuvant, was investigated for the immunomodulatory effects on RAW264.7 …

Marine bivalves living in pollution-prone coastal areas may be simultaneously coexposed to
veterinary antibiotic residuals and microplastics (MPs). However, the synergistic effects of …

Gonadal development is a prerequisite for the reproductive success of an organism, and
might be affected by environmental factors such as emergent pollutants. Although marine …

Four polysaccharides (AEPA, AEPB, AEPC and AEPD) isolated and purified from the roots
of Actinidia eriantha using gel filtration were subjected to composition analysis and valuated …

Intestinal stromal cells are known to modulate the propagation and differentiation of intestinal
stem cells 1 , 2 . However, the precise cellular and molecular mechanisms by which this …