[PDF][PDF] Induced phase separation of mutant NF2 imprisons the cGAS-STING machinery to abrogate antitumor immunity

F Meng, Z Yu, D Zhang, S Chen, H Guan, R Zhou… - Molecular Cell, 2021 - cell.com
Missense mutations of the tumor suppressor Neurofibromin 2 (NF2/Merlin/schwannomin)
result in sporadic to frequent occurrences of tumorigenesis in multiple organs. However, the …

An abnormal size effect enables ampere-level O 2 electroreduction to hydrogen peroxide in neutral electrolytes

…, Y Zhang, K Yang, L Jiang, Z Nie, H Guan… - Energy & …, 2023 - pubs.rsc.org
The principle of size effect was noticed a century ago, and is now widely used to express
the activity enhancement of a catalyst as a result of size decrease. However, there are …

[HTML][HTML] Crystal structure of the receptor binding domain of the spike glycoprotein of human betacoronavirus HKU1

X Ou, H Guan, B Qin, Z Mu, JA Wojdyla, M Wang… - Nature …, 2017 - nature.com
Human coronavirus (CoV) HKU1 is a pathogen causing acute respiratory illnesses and so
far little is known about its biology. HKU1 virus uses its S1 subunit C-terminal domain (CTD) …

Crystal structure of 2C helicase from enterovirus 71

H Guan, J Tian, B Qin, JA Wojdyla, B Wang, Z Zhao… - Science …, 2017 - science.org
Enterovirus 71 (EV71) is the major pathogen responsible for outbreaks of hand, foot, and
mouth disease. EV71 nonstructural protein 2C participates in many critical events throughout …

[PDF][PDF] TBK1-mediated DRP1 targeting confers nucleic acid sensing to reprogram mitochondrial dynamics and physiology

S Chen, S Liu, J Wang, Q Wu, A Wang, H Guan… - Molecular Cell, 2020 - cell.com
Mitochondrial morphology shifts rapidly to manage cellular metabolism, organelle integrity,
and cell fate. It remains unknown whether innate nucleic acid sensing, the central and …

FeMn bimetallic MOF directly applicable as an efficient electrocatalyst for overall water splitting

H Guan, N Wang, X Feng, S Bian, W Li… - Colloids and Surfaces A …, 2021 - Elsevier
The preparation of high-efficiency, stable and low-cost oxygen evolution reaction (OER) and
hydrogen evolution reaction (HER) electrocatalysts is always a challenge for new energy …

Legionella pneumophila regulates the activity of UBE2N by deamidase‐mediated deubiquitination

N Gan, H Guan, Y Huang, T Yu, J Fu… - The EMBO …, 2020 - embopress.org
The Legionella pneumophila effector MavC induces ubiquitination of the E2 ubiquitin‐conjugating
enzyme UBE 2N by transglutamination, thereby abolishing its function in the synthesis …

[HTML][HTML] Cryo-EM structures of the human PA200 and PA200-20S complex reveal regulation of proteasome gate opening and two PA200 apertures

H Guan, Y Wang, T Yu, Y Huang, M Li… - PLoS …, 2020 - journals.plos.org
Proteasomes are highly abundant and conserved protease complexes that eliminate unwanted
proteins in the cells. As a single-chain ATP-independent nuclear proteasome activator, …

Regulation of cGAS‐Mediated Immune Responses and Immunotherapy

AFUH Saeed, X Ruan, H Guan, J Su… - Advanced …, 2020 - Wiley Online Library
Early detection of infectious nucleic acids released from invading pathogens by the innate
immune system is critical for immune defense. Detection of these nucleic acids by host …

S element-doped synergistically well-mixed MOFs as highly efficient oxygen precipitation electrocatalyst

H Guan, N Wang, X Feng, S Bian, Y Liu, M Ma… - International Journal of …, 2020 - Elsevier
The design of satisfied catalytic activity and stable catalysts for the oxygen evolution reaction
(OER) is crucial in the production of hydrogen in electrolyzed water. Herein, S-doping NiCo-…