[HTML][HTML] The role of Ku70 as a cytosolic DNA sensor in innate immunity and beyond
Human Ku70 is a well-known endogenous nuclear protein involved in the non-homologous
end joining pathway to repair double-stranded breaks in DNA. However, Ku70 has been …
end joining pathway to repair double-stranded breaks in DNA. However, Ku70 has been …
Intranasal vaccination of recombinant adeno-associated virus encoding receptor-binding domain of severe acute respiratory syndrome coronavirus (SARS-CoV) spike …
L Du, G Zhao, Y Lin, H Sui, C Chan, S Ma… - The Journal of …, 2008 - journals.aai.org
We have previously reported that a subunit protein vaccine based on the receptor-binding
domain (RBD) of severe acute respiratory syndrome coronavirus (SARS-CoV) spike protein …
domain (RBD) of severe acute respiratory syndrome coronavirus (SARS-CoV) spike protein …
STING is an essential mediator of the Ku70-mediated production of IFN-λ1 in response to exogenous DNA
H Sui, M Zhou, H Imamichi, X Jiao, BT Sherman… - Science …, 2017 - science.org
We previously identified Ku70, a subunit of a DNA repair protein complex, as a cytosolic
DNA sensor that induces the production of interferon-λ1 (IFN-λ1) by human primary cells and …
DNA sensor that induces the production of interferon-λ1 (IFN-λ1) by human primary cells and …
[HTML][HTML] An M2e-based multiple antigenic peptide vaccine protects mice from lethal challenge with divergent H5N1 influenza viruses
G Zhao, Y Lin, L Du, J Guan, S Sun, H Sui, Z Kou… - Virology journal, 2010 - Springer
Background A growing concern has raised regarding the pandemic potential of the highly
pathogenic avian influenza (HPAI) H5N1 viruses. Consequently, there is an urgent need to …
pathogenic avian influenza (HPAI) H5N1 viruses. Consequently, there is an urgent need to …
Cytoplasmic‐translocated Ku70 senses intracellular DNA and mediates interferon‐lambda1 induction
H Sui, Q Chen, T Imamichi - Immunology, 2021 - Wiley Online Library
We have previously identified that human Ku70, a nuclear protein, serves as a cytosolic DNA
sensor. Upon transfection with DNA or infection with DNA virus, Ku70 translocates from the …
sensor. Upon transfection with DNA or infection with DNA virus, Ku70 translocates from the …
[HTML][HTML] Interleukin-27 Is a Potent Inhibitor of cis HIV-1 Replication in Monocyte-Derived Dendritic Cells via a Type I Interferon-Independent Pathway
Q Chen, S Swaminathan, D Yang, L Dai, H Sui, J Yang… - PloS one, 2013 - journals.plos.org
IL-27, a member of the IL-12 family of cytokines, plays an important and diverse role in the
function of the immune system. Whilst generally recognized as an anti-inflammatory cytokine, …
function of the immune system. Whilst generally recognized as an anti-inflammatory cytokine, …
siRNA enhances DNA-mediated interferon lambda-1 response through crosstalk between RIG-I and IFI16 signalling pathway
H Sui, M Zhou, Q Chen, HC Lane… - Nucleic acids …, 2014 - academic.oup.com
In addition to silencing specific genes, small interfering RNA (siRNA) transfection is also
associated with the non-specific induction of inflammatory cytokines and type I interferon. Those …
associated with the non-specific induction of inflammatory cytokines and type I interferon. Those …
[PDF][PDF] Manganese enhances DNA-or RNA-mediated innate immune response by inducing phosphorylation of TANK-binding kinase 1
H Sui, Q Chen, J Yang, S Srirattanapirom, T Imamichi - Iscience, 2022 - cell.com
Trace metals are essential for various physiological processes, but their roles in innate
immunity have not been fully explored. Here, we found that manganese (Mn) significantly …
immunity have not been fully explored. Here, we found that manganese (Mn) significantly …
[HTML][HTML] Small interfering RNA targeting m2 gene induces effective and long term inhibition of influenza A virus replication
HY Sui, GY Zhao, JD Huang, DY Jin, KY Yuen… - PloS one, 2009 - journals.plos.org
RNA interference (RNAi) provides a powerful new means to inhibit viral infection specifically.
However, the selection of siRNA-resistant viruses is a major concern in the use of RNAi as …
However, the selection of siRNA-resistant viruses is a major concern in the use of RNAi as …
[HTML][HTML] Interleukin-27 Enhances the potential of reactive oxygen species generation from monocyte-derived macrophages and dendritic cells by induction of p47phox
Interleukin (IL)-27, a member of the IL-12 cytokine family, plays an important and diverse role
in the function of the immune system. We have previously demonstrated that IL-27 is an anti…
in the function of the immune system. We have previously demonstrated that IL-27 is an anti…