Exceptionally long-lived species, including many bats, rarely show overt signs of aging,
making it difficult to determine why species differ in lifespan. Here, we use DNA methylation (…

The aim of this review is to provide an updated review of the epigenetic factors involved in the
onset and development of osteoarthritis (OA). OA is a prevalent degenerative joint disease …

Complex Lymphatic Anomalies (CLA) are lymphatic malformations with idiopathic bone and
soft tissue involvement. The extent of the abnormal lymphatic presentation and boney …

Objective Lysosomes are the major catabolic organelle of the cell and regulate the
macromolecular and organelle turnover and programmed cell death. Here, we investigated the …

Leptin is a pleiotropic protein best known for regulation of appetite and fat storage in mammals.
While many leptin orthologs have been identified among vertebrates, an authentic leptin …

Low bone mineral density (BMD) is a significant comorbidity in Alzheimer's disease (AD)
and may reflect systemic regulatory pathway dysfunction. Low BMD has been identified in …

Vespertilionid bats (Mammalia: Order Chiroptera) live 3–10 times longer than other mammals
of an equivalent body size. At present, nothing is known of how bat fecal metabolic profiles …

Complex lymphatic anomalies (CLAs) are a set of rare diseases with unique osteopathic
profiles. Recent efforts have identified how lymphatic-specific somatic activating mutations can …

Cetacean evolution was shaped by an extraordinary land‐to‐sea transition in which the
ancestors of whales became fully aquatic. As part of this transition, these mammals evolved …

… These rest on and reproduce endless cycles of hope and despair driven by the SOE’s
project of redemption. We are defined in our relation to this hope, in our commitment to the …