Atrial fibrillation (AF) is known to be the most common supraventricular arrhythmia affecting
up to 1% of the general population. Its prevalence exponentially increases with age and …

Hemolytic anemias are very common diseases. Among these diseases, hemoglobinopathies
are widely spread throughout the Mediterranean Basin, including North Africa (Tunisia, …

Aims Non-coding RNA has been recently demonstrated to be a novel mechanism for
modulation of gene expression at the post-transcriptional level. The importance of microRNAs in …

The development of the heart is a complex process during which different cell types
progressively contribute to shape a four-chambered pumping organ. Over the last decades, our …

The endoplasmic reticulum (ER) is a principal subcellular organelle responsible for protein
quality control in the secretory pathway, preventing protein misfolding and aggregation. …

Background— Pitx2 is a homeobox transcription factor that plays a pivotal role in early left/right
determination during embryonic development. Pitx2 loss-of-function mouse mutants …

Na v 1.5 is the predominant cardiac sodium channel subtype, encoded by the SCN5A gene,
which is involved in the initiation and conduction of action potentials throughout the heart. …

Background Brugada syndrome (BrS) is a rare inherited cardiac arrhythmia associated with
a high risk of sudden cardiac death (SCD) due to ventricular fibrillation (VF). BrS is …

Aims Atrial fibrillation (AF) is the most common type of arrhythmia in humans, yet the genetic
cause of AF remains elusive. Genome-wide association studies (GWASs) have reported risk …

Background The human cardiac action potential in atrial and ventricular cells is initiated by
a fast-activating, fast-inactivating sodium current generated by the SCN5A/Na v 1.5 channel …