The role of withdrawal‐related phenomena in the development and maintenance of alcohol
addiction remains under debate. A ‘self‐medication’ framework postulates that emotional …

Background: The development of dependence may have significant motivational consequences
regarding continued use and abuse of ethanol. We have developed a mouse model of …

Prior experience with ethanol (EtOH) withdrawal may sensitize an individual to subsequent
withdrawal episodes. It has been hypothesized that the progressive intensification of the …

Continued excessive alcohol consumption can lead to the development of dependence that
is associated with a withdrawal syndrome when alcohol consumption is ceased or …

Introduction: Some anticonvulsants ameliorate signs and symptoms of alcohol withdrawal,
but have an unacceptable side effect burden. Among the advantages of using anticonvulsant …

Rationale While stress is often proposed to play a significant role in influencing alcohol
consumption, the relationship between stress and alcohol is complex and poorly understood. …

Rationale We previously demonstrated that chronic ethanol exposure and withdrawal
experience significantly increased subsequent voluntary ethanol intake in C57BL/6J mice. This …

In the present study, we used a mouse model of chronic intermittent ethanol (CIE) exposure
to examine how CIE alters the plasticity of the medial prefrontal cortex (mPFC). In acute …

In many alcoholics, the severity of withdrawal symptoms increases after repeated withdrawal
episodes. This exacerbation may be attributable to a kindling process. Kindling is a …

Stress is commonly regarded as an important trigger for relapse and a significant factor that
promotes increased motivation to drink in some individuals. However, the relationship …