User profiles for Howard Chang
 | Howard Y. ChangStanford University Verified email at stanford.edu Cited by 129913 |
ATAC‐seq: a method for assaying chromatin accessibility genome‐wide
JD Buenrostro, B Wu, HY Chang… - Current protocols in …, 2015 - Wiley Online Library
This unit describes Assay for Transposase‐Accessible Chromatin with high‐throughput
sequencing (ATAC‐seq), a method for mapping chromatin accessibility genome‐wide. This …
sequencing (ATAC‐seq), a method for mapping chromatin accessibility genome‐wide. This …
[PDF][PDF] Long noncoding RNAs in cancer pathways
AM Schmitt, HY Chang - Cancer cell, 2016 - cell.com
Genome-wide cancer mutation analyses are revealing an extensive landscape of functional
mutations within the noncoding genome, with profound effects on the expression of long …
mutations within the noncoding genome, with profound effects on the expression of long …
Long non-coding RNA HOTAIR reprograms chromatin state to promote cancer metastasis
Large intervening non-coding RNAs (lincRNAs) are pervasively transcribed in the genome 1
, 2 , 3 yet their potential involvement in human disease is not well understood 4 , 5 . Recent …
, 2 , 3 yet their potential involvement in human disease is not well understood 4 , 5 . Recent …
Gene regulation in the immune system by long noncoding RNAs
Long noncoding RNAs (lncRNAs) are emerging as critical regulators of gene expression in
the immune system. Studies have shown that lncRNAs are expressed in a highly lineage-…
the immune system. Studies have shown that lncRNAs are expressed in a highly lineage-…
Genome regulation by long noncoding RNAs
The central dogma of gene expression is that DNA is transcribed into messenger RNAs, which
in turn serve as the template for protein synthesis. The discovery of extensive transcription …
in turn serve as the template for protein synthesis. The discovery of extensive transcription …
Transposition of native chromatin for fast and sensitive epigenomic profiling of open chromatin, DNA-binding proteins and nucleosome position
We describe an assay for transposase-accessible chromatin using sequencing (ATAC-seq),
based on direct in vitro transposition of sequencing adaptors into native chromatin, as a …
based on direct in vitro transposition of sequencing adaptors into native chromatin, as a …
Long noncoding RNA as modular scaffold of histone modification complexes
Long intergenic noncoding RNAs (lincRNAs) regulate chromatin states and epigenetic
inheritance. Here, we show that the lincRNA HOTAIR serves as a scaffold for at least two distinct …
inheritance. Here, we show that the lincRNA HOTAIR serves as a scaffold for at least two distinct …
[PDF][PDF] Molecular mechanisms of long noncoding RNAs
KC Wang, HY Chang - Molecular cell, 2011 - cell.com
Long noncoding RNAs (lncRNAs) are an important class of pervasive genes involved in a
variety of biological functions. Here we discuss the emerging archetypes of molecular …
variety of biological functions. Here we discuss the emerging archetypes of molecular …
A long noncoding RNA maintains active chromatin to coordinate homeotic gene expression
The genome is extensively transcribed into long intergenic noncoding RNAs (lincRNAs),
many of which are implicated in gene silencing 1 , 2 . Potential roles of lincRNAs in gene …
many of which are implicated in gene silencing 1 , 2 . Potential roles of lincRNAs in gene …
[HTML][HTML] Functional demarcation of active and silent chromatin domains in human HOX loci by noncoding RNAs
Noncoding RNAs (ncRNA) participate in epigenetic regulation but are poorly understood.
Here we characterize the transcriptional landscape of the four human HOX loci at five base …
Here we characterize the transcriptional landscape of the four human HOX loci at five base …