Allergic inflammatory memory in human respiratory epithelial progenitor cells
…, E Yoshimoto, KN Cahill, N Bhattacharyya, HR Katz… - Nature, 2018 - nature.com
Barrier tissue dysfunction is a fundamental feature of chronic human inflammatory diseases
1. Specialized subsets of epithelial cells—including secretory and ciliated cells—differentiate …
1. Specialized subsets of epithelial cells—including secretory and ciliated cells—differentiate …
Interleukin 3: A differentiation and growth factor for the mouse mast cell that contains chondroitin sulfate E proteoglycan.
…, D Seldin, JM Mencia-Huerta, HR Katz… - … (Baltimore, Md.: 1950 …, 1984 - journals.aai.org
Mouse mast cells were differentiated and grown by culturing bone marrow cells in medium
containing 2 X 10(-10) M purified interleukin 3 (IL 3). The cells obtained were similar in …
containing 2 X 10(-10) M purified interleukin 3 (IL 3). The cells obtained were similar in …
[HTML][HTML] KIT inhibition by imatinib in patients with severe refractory asthma
KN Cahill, HR Katz, J Cui, J Lai, S Kazani… - … England Journal of …, 2017 - Mass Medical Soc
Background Mast cells are present in the airways of patients who have severe asthma despite
glucocorticoid treatment; these cells are associated with disease characteristics including …
glucocorticoid treatment; these cells are associated with disease characteristics including …
Mast cell deficiency in KitW-sh mice does not impair antibody-mediated arthritis
…, W Xing, DS Friend, KF Austen, HR Katz - The Journal of …, 2007 - rupress.org
We previously reported that joint swelling, synovial thickening, and cartilage matrix depletion
induced by the injection of anti-collagen monoclonal antibodies and lipopolysaccharide (…
induced by the injection of anti-collagen monoclonal antibodies and lipopolysaccharide (…
Human airway mast cells proliferate and acquire distinct inflammation-driven phenotypes during type 2 inflammation
…, B Berger, N Bhattacharyya, RE Roditi, HR Katz… - Science …, 2021 - science.org
Mast cells (MCs) play a pathobiologic role in type 2 (T2) allergic inflammatory diseases of
the airway, including asthma and chronic rhinosinusitis with nasal polyposis (CRSwNP). …
the airway, including asthma and chronic rhinosinusitis with nasal polyposis (CRSwNP). …
Thymic stromal lymphopoietin controls prostaglandin D2 generation in patients with aspirin-exacerbated respiratory disease
KM Buchheit, KN Cahill, HR Katz, KC Murphy… - Journal of Allergy and …, 2016 - Elsevier
Background Prostaglandin (PG) D 2 is the dominant COX product of mast cells and is an
effector of aspirin-induced respiratory reactions in patients with aspirin-exacerbated respiratory …
effector of aspirin-induced respiratory reactions in patients with aspirin-exacerbated respiratory …
Aspirin-exacerbated respiratory disease involves a cysteinyl leukotriene–driven IL-33–mediated mast cell activation pathway
…, N Bhattacharya, TM Laidlaw, HR Katz… - The Journal of …, 2015 - journals.aai.org
Aspirin-exacerbated respiratory disease (AERD), a severe eosinophilic inflammatory disorder
of the airways, involves overproduction of cysteinyl leukotrienes (cysLTs), activation of …
of the airways, involves overproduction of cysteinyl leukotrienes (cysLTs), activation of …
Prostaglandin E2 deficiency causes a phenotype of aspirin sensitivity that depends on platelets and cysteinyl leukotrienes
T Liu, TM Laidlaw, HR Katz… - Proceedings of the …, 2013 - National Acad Sciences
Aspirin-exacerbated respiratory disease (AERD) is characterized by asthma, tissue
eosinophilia, overproduction of cysteinyl leukotrienes (cysLTs), and respiratory reactions to …
eosinophilia, overproduction of cysteinyl leukotrienes (cysLTs), and respiratory reactions to …
Mouse mast cell gp49B1 contains two immunoreceptor tyrosine-based inhibition motifs and suppresses mast cell activation when coligated with the high-affinity Fc …
HR Katz, E Vivier, MC Castells… - Proceedings of the …, 1996 - National Acad Sciences
Mouse mast cells express gp49B1, a cell-surface member of the Ig superfamily encoded by
the gp49B gene. We now report that by ALIGN comparison of the amino acid sequence of …
the gp49B gene. We now report that by ALIGN comparison of the amino acid sequence of …
[HTML][HTML] SLP-76 deficiency impairs signaling via the high-affinity IgE receptor in mast cells
…, TR Martin, JM Lu-Kuo, HR Katz… - Journal of Clinical …, 1999 - ncbi.nlm.nih.gov
SLP-76 is an adapter protein expressed in T cells and myeloid cells that is a substrate for
ZAP-70 and Syk. SLP-76–deficient mice exhibit a profound block in T-cell development. We …
ZAP-70 and Syk. SLP-76–deficient mice exhibit a profound block in T-cell development. We …