Long-term potentiation (LTP) in the CA1 region of the hippocampus has been the primary
model by which to study the cellular and molecular basis of memory. Calcium/calmodulin-…

The transduction of many cellular stimuli results in oscillations in the intracellular concentration
of calcium ions (Ca 2+ ). Although information is thought to be encoded in the frequency …

Calcium- and calmodulin-dependent protein kinase II (CaMKII) and glutamate receptors are
integrally involved in forms of synaptic plasticity that may underlie learning and memory. In …

The regulation of cellular function by hormones and extracellular molecules, which bind to
cell surface receptors, is initiated by signal transduction mechн anisms at the plasma …

Most hormones, neurotransmitters, and other signalling molecules stimulate receptors that
are coupled to the generation of the second messengers cAMP, diacylglycerol, and Ca2+. …

Ca 2+ /calmodulin (CaM)-dependent protein kinase (CaMKII) is a ubiquitous mediator of Ca
2+ -linked signalling that phosphorylates a wide range of substrates to co-ordinate and …

Ca 2+ -dependent facilitation (CDF) of voltage-gated calcium current is a powerful mechanism
for up-regulation of Ca 2+ influx during repeated membrane depolarization. CDF of L-type …

Long-term potentiation (LTP) of synaptic transmission is a widely studied cellular example of
synaptic plasticity. However, the identity, localization, and interplay among the biochemical …

▪ Abstract Highly enriched in brain tissue and present throughout the body, Ca 2+ /calmodulin-dependent
protein kinase II (CaMKII) is central to the coordination and execution of Ca 2+ …

Multifunctional calcium-calmodulin-dependent protein kinase (CaM kinase) transduces transient
elevations in intracellular calcium into changes in the phosphorylation state and activity …