In situ programming of leukaemia-specific T cells using synthetic DNA nanocarriers
TT Smith, SB Stephan, HF Moffett, LE McKnight… - Nature …, 2017 - nature.com
An emerging approach for treating cancer involves programming patient-derived T cells
with genes encoding disease-specific chimeric antigen receptors (CARs), so that they can …
with genes encoding disease-specific chimeric antigen receptors (CARs), so that they can …
[HTML][HTML] Biopolymers codelivering engineered T cells and STING agonists can eliminate heterogeneous tumors
TT Smith, HF Moffett, SB Stephan… - The Journal of …, 2017 - Am Soc Clin Investig
Therapies using T cells that are programmed to express chimeric antigen receptors (CAR T
cells) consistently produce positive results in patients with hematologic malignancies. …
cells) consistently produce positive results in patients with hematologic malignancies. …
B cells engineered to express pathogen-specific antibodies protect against infection
HF Moffett, CK Harms, KS Fitzpatrick, MR Tooley… - Science …, 2019 - science.org
Effective vaccines inducing lifelong protection against many important infections such as
respiratory syncytial virus (RSV), HIV, influenza virus, and Epstein-Barr virus (EBV) are not yet …
respiratory syncytial virus (RSV), HIV, influenza virus, and Epstein-Barr virus (EBV) are not yet …
Beyond Help: Direct Effector Functions of Human Immunodeficiency Virus Type 1-Specific CD4+ T Cells
The immune correlates of protection in human immunodeficiency virus type 1 (HIV-1) infection
remain poorly defined, particularly the contribution of CD4 + T cells. Here we explore the …
remain poorly defined, particularly the contribution of CD4 + T cells. Here we explore the …
[HTML][HTML] MicroRNA expression profiling identifies activated B cell status in chronic lymphocytic leukemia cells
S Li, HF Moffett, J Lu, L Werner, H Zhang, J Ritz… - PloS one, 2011 - journals.plos.org
Chronic lymphocytic leukemia (CLL) is thought to be a disease of resting lymphocytes.
However, recent data suggest that CLL cells may more closely resemble activated B cells. Using …
However, recent data suggest that CLL cells may more closely resemble activated B cells. Using …
The microRNA miR-31 inhibits CD8+ T cell function in chronic viral infection
During infection, antigen-specific T cells undergo tightly regulated developmental transitions
controlled by transcriptional and post-transcriptional regulation of gene expression. We …
controlled by transcriptional and post-transcriptional regulation of gene expression. We …
Heat shock protein-mediated cross-presentation of exogenous HIV antigen on HLA class I and class II
…, M Hassan-Zahraee, HF Moffett… - The Journal of …, 2004 - journals.aai.org
Strong CD4+ and CD8+ T cell responses are considered important immune components for
controlling HIV infection, and their priming may be central to an effective HIV vaccine. We …
controlling HIV infection, and their priming may be central to an effective HIV vaccine. We …
Not miR-ly small RNAs: big potential for microRNAs in therapy
TM Love, HF Moffett, CD Novina - Journal of allergy and clinical …, 2008 - Elsevier
RNA interference (RNAi) describes a set of natural processes in which genes are silenced by
small RNAs. RNAi has been widely used as an experimental tool that has recently become …
small RNAs. RNAi has been widely used as an experimental tool that has recently become …
Multiple Effector Functions Mediated by Human Immunodeficiency Virus-Specific CD4+ T-Cell Clones
PJ Norris, M Sumaroka, C Brander, HF Moffett… - Journal of …, 2001 - Am Soc Microbiol
Mounting evidence suggests that human immunodeficiency virus type 1 (HIV-1) Gag-specific
T helper cells contribute to effective antiviral control, but their functional characteristics and …
T helper cells contribute to effective antiviral control, but their functional characteristics and …
Fine Specificity and Cross-Clade Reactivity of HIV Type 1 Gag-Specific CD4+ T Cells
Despite growing evidence that HIV-1-specific CD4 + T helper (Th) cells may play a role in
the control of viremia, discrete Th cell epitopes remain poorly defined. Furthermore, it is not …
the control of viremia, discrete Th cell epitopes remain poorly defined. Furthermore, it is not …