Severe lymphopenia is associated with elevated plasma interleukin-15 levels and increased mortality during severe sepsis

…, YT Huang, CC Chen, MR Lee, YJ Chen, HH Hou… - Shock, 2015 - journals.lww.com
Sepsis-related mortality has been found increased in RAG-1 knockout mice. However, in
patients admitted to medical intensive care units, it is unknown whether severe lymphocyte …

N-terminal domain of soluble epoxide hydrolase negatively regulates the VEGF-mediated activation of endothelial nitric oxide synthase

HH Hou, BD Hammock, KH Su… - Cardiovascular …, 2012 - academic.oup.com
Aims The mammalian soluble epoxide hydrolase (sEH) has both an epoxide hydrolase and
a phosphatase domain. The role of sEH hydrolase activity in the metabolism of …

Elastase induces lung epithelial cell autophagy through placental growth factor: a new insight of emphysema pathogenesis

HH Hou, SL Cheng, KP Chung, MYP Kuo, CC Yeh… - Autophagy, 2014 - Taylor & Francis
Chronic obstructive pulmonary disease (COPD) is a devastating disease, which is associated
with increasing mortality and morbidity. Therefore, there is a need to clearly define the …

[HTML][HTML] Implication of AMP-activated protein kinase in transient receptor potential vanilloid type 1-mediated activation of endothelial nitric oxide synthase

LC Ching, CY Chen, KH Su, HH Hou, SK Shyue… - Molecular …, 2012 - Springer
We investigated whether AMP-activated protein kinase (AMPK), a multifunctional regulator
of energy homeostasis, is involved in transient receptor potential vanilloid type 1 (TRPV1)-…

Valsartan regulates the interaction of angiotensin II type 1 receptor and endothelial nitric oxide synthase via Src/PI3K/Akt signalling

…, AN Chiang, SH Hsiao, YL Wu, HH Hou… - Cardiovascular …, 2009 - academic.oup.com
Aims Valsartan, a selective angiotensin II type 1 receptor (AT 1 R) blocker, has beneficial
effects in the cardiovascular system in part by its increase of nitric oxide (NO) bioavailability, yet …

MMP-12 activates protease-activated receptor-1, upregulates placenta growth factor, and leads to pulmonary emphysema

HH Hou, HC Wang, SL Cheng… - American Journal of …, 2018 - journals.physiology.org
Because of the expansion of aging and smoking populations, chronic obstructive pulmonary
disease (COPD) is predicted to be the third leading cause of death worldwide in 2030. …

[HTML][HTML] Fucosyltransferase 4 shapes oncogenic glycoproteome to drive metastasis of lung adenocarcinoma

…, SY Lin, RR Weng, YH Juan, YW Chen, HH Hou… - …, 2020 - thelancet.com
Background Aberrant fucosylation plays a critical role in lung cancer progression. Nevertheless,
the key fucosyltransferase with prognostic significance in lung cancer patients, the …

AMP‐activated protein kinase mediates erythropoietin‐induced activation of endothelial nitric oxide synthase

KH Su, YB Yu, HH Hou, JF Zhao… - Journal of cellular …, 2012 - Wiley Online Library
We investigated whether AMP‐activated protein kinase (AMPK), a multi‐functional regulator
of energy homeostasis, participates in the regulation of erythropoietin (EPO)‐mediated …

Autophagy in fibroblasts induced by cigarette smoke extract promotes invasion in lung cancer cells

HH Hou, HJ Pan, WY Liao, CH Lee… - International Journal of …, 2020 - Wiley Online Library
We investigated the effects of cigarette smoke extract (CSE) on lung fibroblasts and found that
the invasiveness of lung cancer cells was facilitated by the conditioned medium from CSE‐…

[HTML][HTML] Role of phosphatase activity of soluble epoxide hydrolase in regulating simvastatin-activated endothelial nitric oxide synthase

HH Hou, YJ Liao, SH Hsiao, SK Shyue, TS Lee - Scientific Reports, 2015 - nature.com
Soluble epoxide hydrolase (sEH) has C-terminal epoxide hydrolase and N-terminal lipid
phosphatase activity. Its hydrolase activity is associated with endothelial nitric oxide synthase (…