Ferroptotic death is the penalty for losing control over three processes—iron metabolism,
lipid peroxidation and thiol regulation—that are common in the pro-inflammatory environment …

Ferroptosis is a death program executed via selective oxidation of arachidonic acid–phosphatidylethanolamines
(AA-PE) by 15-lipoxygenases. In mammalian cells and tissues, …

sn2-15-Hydroperoxy-eicasotetraenoyl-phosphatidylethanolamines (sn2-15-HpETE-PE)
generated by mammalian 15-lipoxygenase/phosphatidylethanolamine binding protein-1 (15-LO/…

Pancreatic ductal adenocarcinoma (PDAC) is a lethal malignancy with limited treatment
options. Although activating mutations of the KRAS GTPase are the predominant dependency …

Background ParaHox and Hox genes are thought to have evolved from a common ancestral
ProtoHox cluster or from tandem duplication prior to the divergence of cnidarians and …

Background Supplemented fatty acids can incorporate into cardiolipin (CL) and affect its
remodeling. The change in CL species may alter the mitochondrial membrane composition, …

Cardiolipin (CL) is a unique phospholipid localized almost exclusively within the mitochondrial
membranes where it is synthesized. Newly synthesized CL undergoes acyl remodeling to …

A defining feature of chordates is the unique presence of a dorsal hollow neural tube that
forms by internalization of the ectodermal neural plate specified via inhibition of BMP signaling …

Docosahexaenoic acid (DHA) and eicosapentaenoic acid (EPA), known as ω-3 polyunsaturated
fatty acid (PUFA), are common nutrients in daily food intake and have been shown to …

Background Mesoderm is generally considered to be a germ layer that is unique to Bilateria,
and it develops into diverse tissues, including muscle, and in the case of vertebrates, the …