Myelin is a defining feature of the vertebrate nervous system. Variability in the thickness of
the myelin envelope is a structural feature affecting the conduction of neuronal signals. …

Murine pluripotent stem cells can exist in two functionally distinct states, LIF-dependent
embryonic stem cells (ESCs) and bFGF-dependent epiblast stem cells (EpiSCs). However, …

Neuronal development requires a complex choreography of transcriptional decisions to
obtain specific cellular identities. Realizing the ultimate goal of identifying genome-wide …

Pluripotent stem cell lines can be derived from blastocyst embryos, which yield embryonic
stem cell lines (ES cells), as well as the postimplantation epiblast, which gives rise to epiblast …

Age-related macular degeneration (AMD) is a leading cause of vision loss. To better understand
disease pathogenesis and identify causal genes in GWAS loci for AMD risk, we present …

Tau is an axonal microtubule-binding protein. Tau pathology in brain and increased tau
concentration in the cerebrospinal fluid (CSF) are hallmarks of Alzheimer’s disease (AD). Most of …

L3mbtl2 has been implicated in transcriptional repression and chromatin compaction but its
biological function has not been defined. Here we show that disruption of L3mbtl2 results in …

The neocortex contains an unparalleled diversity of neuronal subtypes, each defined by
distinct traits that are developmentally acquired under the control of subtype-specific and pan-…

The scarcity of primordial germ cells (PGCs) in the developing mammalian embryo hampers
robust biochemical analysis of the processes that underlie early germ cell formation. Here, …

Age-related macular degeneration (AMD) is a leading cause of blindness, affecting 200
million people worldwide. To identify genes that could be targeted for treatment, we created a …